Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
The optimized protocol for isolating small extracellular vesicles from small blood volumes, confirmed by independent methods including cryo-electron microscopy, ensures superior purity and high yield for reliable biomarker detection.
Sarah Nicholas, Katja Sporar Klinge ... Karin Nordström
Descending neurons that encode widefield motion vision in the fly have sexually dimorphic velocity tuning, while the wing beat amplitude, which these neurons presumably control, is monomorphic.
Exploring the differentiation of iPSC to trunk tenocytes and how the single-cell RNA sequencing and pathway analysis can assist in making it more specific.
Dana MS Cheung, Momchil Razsolkov ... J Simon C Arthur
B cell activation and antibody class switching requires coordinated metabolic rewiring, with essential roles for amino acid transport, cholesterol metabolism, and prenylation in driving proliferation across multiple activating stimuli.
Alina-Măriuca Marinescu, Eshita Kamal ... Marie A Labouesse
Within the nucleus accumbens shell, a spatially defined rostral subregion selectively modulates hedonic feeding, revealing functional heterogeneity in reward circuitry underlying food consumption.
The dynamic internal fluidity of nuclear MORC2 condensates, rather than their mere assembly, is strictly required for transcriptional regulation and is selectively disrupted by neuropathy-linked mutations.
Multimodal stacking of MRI‑based markers of cognition reveals a shared brain architecture that links cognitive performance with mental health, explaining nearly half of their observed association.
EXOC6A cooperates with myosin-Va to regulate vesicle trafficking and membrane remodeling during ciliogenesis, enabling ciliary vesicle maturation, transition zone assembly, and proper delivery of ciliary membrane proteins.
Sofia Lövestam, Jane L Wagstaff ... Sjors HW Scheres
Phosphomimetic mutations allow the assembly of full-length recombinant tau into Alzheimer's paired helical filaments by disrupting intramolecular contacts between its ordered core and fuzzy coat.
