Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Immunology and Inflammation

    Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation

    Dana MS Cheung, Momchil Razsolkov ... J Simon C Arthur
    B cell activation and antibody class switching requires coordinated metabolic rewiring, with essential roles for amino acid transport, cholesterol metabolism, and prenylation in driving proliferation across multiple activating stimuli.
    1. Neuroscience

    The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot

    Alina-Măriuca Marinescu, Eshita Kamal ... Marie A Labouesse
    Within the nucleus accumbens shell, a spatially defined rostral subregion selectively modulates hedonic feeding, revealing functional heterogeneity in reward circuitry underlying food consumption.
    1. Developmental Biology

    Single-cell transcriptomics-informed induced pluripotent stem cells differentiation to tenogenic lineage

    Angela Papalamprou, Victoria Yu ... Dmitriy Sheyn
    Exploring the differentiation of iPSC to trunk tenocytes and how the single-cell RNA sequencing and pathway analysis can assist in making it more specific.
    1. Structural Biology and Molecular Biophysics

    Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

    Sofia Lövestam, Jane L Wagstaff ... Sjors HW Scheres
    Phosphomimetic mutations allow the assembly of full-length recombinant tau into Alzheimer's paired helical filaments by disrupting intramolecular contacts between its ordered core and fuzzy coat.
    1. Neuroscience

    Multimodal MRI marker of cognition explains the association between cognition and mental health in the UK Biobank

    Irina Buianova, Mateus Silvestrin ... Narun Pat
    Multimodal stacking of MRI‑based markers of cognition reveals a shared brain architecture that links cognitive performance with mental health, explaining nearly half of their observed association.
    1. Neuroscience

    Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling

    Stephan Tetenborg, Eyad Shihabeddin ... John O'Brien
    A proximity labeling screen uncovers the proteome of electrical synapses in retinal neurons.
    1. Cell Biology

    The multifaceted role of EXOC6A in ciliogenesis

    Te-Lin Lin, Chien-Ting Wu, Tang K Tang
    EXOC6A cooperates with myosin-Va to regulate vesicle trafficking and membrane remodeling during ciliogenesis, enabling ciliary vesicle maturation, transition zone assembly, and proper delivery of ciliary membrane proteins.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    MORC2 mediates transcriptional regulation through liquid-liquid phase separation

    Yanshen Zhang, Weiya Xu ... Yihui Bi
    The dynamic internal fluidity of nuclear MORC2 condensates, rather than their mere assembly, is strictly required for transcriptional regulation and is selectively disrupted by neuropathy-linked mutations.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Lineage priming and cell type proportioning depends on the interplay between stochastic and deterministic factors

    William Salvidge, Chris Brimson ... Chris Thompson
    Experiments and mathematical modelling show cell fate in Dictyostelium discoideum partly depends on cell-cycle phase, but also on stochastic gene-expression variability which enhances robustness of developmental responses to cell-cycle perturbation.
    1. Neuroscience

    Two neuropeptides that promote blood feeding in Anopheles stephensi mosquitoes

    Prashali Bansal, Roshni Pillai ... Sonia Q Sen
    Neuropeptides sNPF and RYamide promote blood feeding in Anopheles stephensi, a major malarial vector in the Indian subcontinent and West Africa.