Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Philémon Roussel, Mingyi Zhou ... Auguste Genovesio
Metabolic imaging of the Drosophila mushroom body reveals distinct profiles among Kenyon cell subtypes and detects a subtle learning-associated metabolic change.
Drug repurposing analyses show that citalopram exerts anti-tumor effects by targeting C5aR1 on tumor-associated macrophages to enhance phagocytosis and CD8+ T cell immunity.
Muscle stem cells repurpose the tenogenic factor Scx to establish a muscle-specific transcriptional program that sustains stem cell expansion, migration, differentiation, fusion, self-renewal, and survival.
Harrison A Grier, Sohrab Salimian, Matthew T Kaufman
Mouse primary motor and somatosensory cortices contain detailed information about the many time-varying arm and paw joint angles during reaching and grasping, implying a 'low-level' role in controlling these movements.
A multidisciplinary approach demonstrates that glycolysis orchestrates fungal morphogenesis and virulence by regulating the de novo biosynthesis of sulfur-containing amino acids, thereby establishing a novel metabolic paradigm.
Mir195 enables Ebf1-deficient hematopoietic progenitor cells to mature into B cells, suggesting some miRNA can substitute for transcription factors in differentiation.
Small-molecule mitochondrial transcription factor A modulators stabilize mtDNA, preventing cytosolic escape and suppressing cGAS-STING interferon signaling, while improving bioenergetics and fibrosis markers in disease models.
Upregulated expression of transcription factors promoting cone identity in late-stage retinal progenitors drives development of the cone-dominant retina of 13-lined ground squirrels.
The IL-17–Ly6G⁺ granulocyte axis is a key driver and correlate of tuberculosis pathology and represents a potential target for improving vaccine-induced protection and therapeutic outcomes.
