Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    Adult neurogenesis reconciles flexibility and stability of olfactory perceptual memory

    Bennet Sakelaris, Hermann Riecke
    Transient intrinsic properties of young neurons enable fast learning and support memory stability as the neurons mature, offering a coherent view of the function of adult neurogenesis in olfaction.
    1. Genetics and Genomics

    Alternative splicing across the tree of life

    Rebeca de la Fuente, Wladimiro Dı́az-Villanueva ... Andres Moya
    Alternative splicing exhibits lineage-specific variability, with mammals and birds reaching the highest levels despite conserved intron-rich architectures, while unicellular eukaryotes and prokaryotes display only minimal values.
    1. Cell Biology
    2. Developmental Biology

    Cross-species insemination reveals mouse sperm ability to enter and cross the fish micropyle

    Suma Garibova, Eva Stickler ... Matteo Avella
    Mouse sperm are unable to bind the zebrafish chorion, yet a subset of hyperactivated sperm can enter and cross the micropyle, suggesting a conserved mechanism of gamete interaction across species.
    1. Immunology and Inflammation

    Interleukin 10 controls the balance between tolerance, pathogen elimination, and immunopathology in birds

    Dominique Meunier, Ricardo Corona-Torres ... David A Hume
    The impact of IL10 mutation in birds highlights the intrinsic compromise between effective elimination of a pathogen and damage to the host.
    1. Ecology
    2. Physics of Living Systems

    The dominant–egalitarian transition in species-rich communities

    David A Kessler, Nadav M Shnerb
    A model of a species-rich neutral ecosystem, perturbed by environmental noise impacting each species differently, predicts that for large noise the community is dominated by a few species, while for weaker noise it is more egalitarian, with many significant species.
    1. Neuroscience

    Homeostatic synaptic plasticity of miniature excitatory postsynaptic currents in mouse cortical cultures requires neuronal Rab3a

    Andrew G Koesters, Mark M Rich, Kathrin Engisch
    The first demonstration that a protein thought to function presynaptically (Rab3a) is required for homeostatic, activity-dependent synaptic plasticity of quantal size in central neurons.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    HIF1A-mediated pathways promote euploid cell survival in chromosomally mosaic embryos

    Estefania Sanchez-Vasquez, Marianne E Bronner, Magdalena Zernicka-Goetz
    Aneuploid mosaic mouse embryos require hypoxia for survival, and understanding these pathways may inform new strategies to support embryo viability.
    1. Neuroscience

    Age and learning shapes sound representations in auditory cortex during adolescence

    Benedikt Praegel, Feng Chen ... Adi Mizrahi
    Weaker performance in adolescent mice arises from immature cortical representations and cognitive bias, linking developmental changes in behavior with underlying neural coding.
    1. Neuroscience

    Transcranial direct current stimulation modulates primate brain dynamics across states of consciousness

    Guylaine Hoffner, Pablo Castro ... Béchir Jarraya
    The effects of transcranial direct current stimulation on cortical dynamics depend on the state of consciousness and the stimulation polarity.
    1. Neuroscience

    Shared functional organization between pulvinar-cortical and cortico-cortical connectivity and its structural and molecular imaging correlates

    Gianpaolo Antonio Basile, Augusto Ielo ... Alberto Cacciola
    The pulvinar complex harbors multiple representations of cortico-cortical connectivity organized hierarchically across its ventro-dorsal and medio-lateral axes.