Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Prateek D Bansal, Maia Kinnebrew ... Diwakar Shukla
Multiple competing hypotheses concerning the cholesterol accessibility of oncoprotein Smoothened are quantitatively assessed and experimentally validated, showing that cholesterol takes two pathways from either membrane leaflet to the binding sites.
Single-cell transcriptomics data from mouse bone-relevant cells was used to inform human bone mineral density genome-wide association studies and prioritize genetic targets with potential causal roles in the development of osteoporosis.
Mammalian oocytes utilize a conserved combination of cell cycle control, cytoskeletal organization, and polarity pathways that are fundamentally shared with other vertebrates and invertebrates.
Roberta Carloni, Tadhg Devlin ... Robin C Allshire
Synthetic proteins designed to bind specific repetitive DNA sequences in the Trypanosoma brucei genome allow the identification of proteins enriched over different DNA elements.
Proteome-scale visual screening in budding yeast provides a functional catalog of plasma membrane repair proteins and reveals the coordinated cellular responses at the bud tip and the damage site.
Alan Monziani, Juan Pablo Unfried ... Igor Ulitsky
EPB41L4A-AS1, a highly expressed snoRNA host long noncoding RNA, has multiple functions, positive regulation in cis of the EPB41L4A gene and a trans-acting role in supporting proper nucleolar biology.
Comprehensive mapping of wing sensory neurons in Drosophila reveals that some proprioceptors make direct connections onto flight steering motor neurons, enabling rapid feedback control during flight.
Y-complex nucleoporin, Nup107, can regulate ecdysone production by affecting the transcription of Halloween genes and levels of RTK receptor, torso, for the metamorphic transition from larva to pupa.
Zachary L Reitz, Bita Pourmohsenin ... Marnix H Medema
Automated detection of metallophore biosynthesis reveals that metal-chelating non-ribosomal peptides are widespread, chemically diverse, and deeply rooted in bacterial evolution.
