Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework

    Jun Qiu, Guojin Tang ... Peng Zheng
    A hierarchical framework integrating artificial intelligence with chemical principles enables the conversion of fragile α-helices into ultrastable protein scaffolds.
    1. Cell Biology

    Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and glucocerebrosidase activity

    Elsa Meneses-Salas, Moises Castellá ... Albert Lu
    Dysregulated exocytosis of bis(monoacylglycerol)phosphate (BMP)-enriched extracellular vesicles driven by pathogenic LRRK2 activity supports elevated urinary BMP levels and its use as a biomarker for Parkinson's disease.
    1. Microbiology and Infectious Disease

    Peptidoglycan recycling is critical for cell division, cell wall integrity, and β-lactam resistance in Caulobacter crescentus

    Pia Richter, Anna Merz ... Martin Thanbichler
    Peptidoglycan recycling is essential for proper cell growth and intrinsic ampicillin resistance in Caulobacter crescentus, highlighting PG recycling enzymes as potential antibacterial targets.
    1. Neuroscience

    Dynamic modulation of social gaze by sex and familiarity in marmoset dyads

    Feng Xing, Alec G Sheffield ... Anirvan S Nandy
    A fully automated 3D tracking framework reveals that sex and familiarity strongly shape natural social gaze dynamics in freely interacting marmosets.
    1. Cell Biology

    Human receptive endometrial assembloid for deciphering the implantation window

    Yu Zhang, Rusong Zhao ... Han Zhao
    A specialized window-of-implantation endometrial assembloid enables investigation of human endometrial receptivity and maternal-fetal interaction.
    1. Neuroscience

    The self-interest of adolescents overrules cooperation in social dilemmas

    Xiaoyan Wu, Hongyu Fu ... Chao Liu
    Adolescents value reciprocity less than adults, limiting cooperation despite intact learning about others’ behavior.
    1. Microbiology and Infectious Disease

    A conserved mycobacterial nucleomodulin hijacks the host COMPASS complex to reprogram pro-inflammatory transcription and promote intracellular survival

    Liu Chen, Baojie Duan ... Aizhen Guo
    Mycobacterium tuberculosis deploys nucleomodulins to suppress COMPASS-dependent H3K4 methylation, dampening pro-inflammatory gene expression to enhance intracellular survival and uncovering an epigenetic immune-evasion strategy.
    1. Neuroscience

    Human exploration strategically balances approaching and avoiding uncertainty

    Yaniv Abir, Michael Neil Shadlen, Daphna Shohamy
    Strategic avoidance of uncertainty emerges under high cognitive demands, enabling faster decisions without impairing learning.
    1. Neuroscience

    Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons

    Malin Schmidt, Anne Hoffrichter ... Philipp Koch
    Psilocin induces a durable neuroplastic state in human cortical neurons by enhancing BDNF signaling, neurite complexity, synaptogenesis, and synaptic network activity through 5-HT2A receptor-dependent mechanisms.
    1. Immunology and Inflammation

    Nociceptor neurons control pollution-mediated neutrophilic asthma

    Jo-Chiao Wang, Amelia Kulle ... Sebastien Talbot
    Air pollution activates macrophage-derived artemin, sensitizing TRPA1 nociceptors to drive neutrophilic asthma, revealing new therapeutic targets for refractory airway inflammation.
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