Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Exploring the differentiation of iPSC to trunk tenocytes and how the single-cell RNA sequencing and pathway analysis can assist in making it more specific.
Alina-Măriuca Marinescu, Eshita Kamal ... Marie A Labouesse
Within the nucleus accumbens shell, a spatially defined rostral subregion selectively modulates hedonic feeding, revealing functional heterogeneity in reward circuitry underlying food consumption.
Sofia Lövestam, Jane L Wagstaff ... Sjors HW Scheres
Phosphomimetic mutations allow the assembly of full-length recombinant tau into Alzheimer's paired helical filaments by disrupting intramolecular contacts between its ordered core and fuzzy coat.
EXOC6A cooperates with myosin-Va to regulate vesicle trafficking and membrane remodeling during ciliogenesis, enabling ciliary vesicle maturation, transition zone assembly, and proper delivery of ciliary membrane proteins.
Multimodal stacking of MRI‑based markers of cognition reveals a shared brain architecture that links cognitive performance with mental health, explaining nearly half of their observed association.
The dynamic internal fluidity of nuclear MORC2 condensates, rather than their mere assembly, is strictly required for transcriptional regulation and is selectively disrupted by neuropathy-linked mutations.
Ophélie J Gosselin, Michael Taschner ... Stephan Gruber
A screen using in vitro-selected synthetic nanobodies identified inhibitors of SMC protein function in bacterial cells, revealing a coiled coil region as a vital component of the chromosome-folding machinery.
Sourav Banerjee, Nicola Minshall ... Mark Carrington
The glycosylphosphatidylinositol (GPI)-anchored receptors in Trypanosoma brucei are not confined to the flagellar pocket but instead localise across the whole cell surface, reshaping our understanding of host immune evasion and nutrient uptake.
