Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
The supraspinal system of larval zebrafish has been described, uncovering spinal projections from the telencephalon, mesencephalon, and rhombencephalon, as well as numerous motor and neuromodulatory nuclei conserved with mammals.
Mapping the molecular interactions between polymyxins and hPepT2 enables rational design of safer lipopeptide antibiotics with reduced renal toxicity while retaining antibacterial activity.
In the presence of emulated cone loss, eye movements are used to gather and integrate information, leading to improved letter acuity compared to a non-moving condition.
Ishmael Nii Ayibontey Tagoe, Amanpreet Kaur ... Malini Raghavan
Endoplasmic reticulum and cytosolic calcium levels, and store-operated calcium entry, are comparable in calreticulin-deficient cells rescued with either wild-type calreticulin or the myeloproliferative neoplasm-linked Del52 mutant.
Sung Hoon Cho, Shawna K Brookens ... Mark R Boothby
Genetic and biochemical analyses reveal a way to overcome the metabolic flexibility of B cells and undermine their cytokine receptor signaling and differentiation into antibody-secreting cells, therapeutic targets in systemic lupus erythematosus (SLE).
Structural and biochemical analyses reveal how E. coli FtsEX accommodates EnvC asymmetry to regulate amidase activation during bacterial cell division.
Mayra Patricia Garcia Alcala, Josiah C Kratz, Philippe Cluzel
Surprisingly, monitoring single bacteria expressing constitutive or flagellar genes reveals faster growth, a benefit driven by inherited, cost-free growth factors, whereas bulk measurements show an expected net fitness cost.
During the establishment of size-based dominance hierarchies in clown anemonefish, an individual's social context shapes its growth trajectory through coordinated changes in feeding behavior, aggressive behaviors, and gene expression.
