Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Restitution of RAP2A, human homolog of Drosophila asymmetric cell division regulator Rap2l, in glioblastoma neurosphere cultures targets the stemness of glioblastoma stem cells and could contribute to reduce glioblastoma expansion.
Luz Saavedra-Sanchez, Mary S Dickinson ... Jorn Coers
The enteric bacterial Shigella secretes a virulence factor that degrades the pivotal human defense protein RNF213, thereby protecting cytosolic bacteria from interferon-driven ubiquitylation and associated innate immunity.
Zachary W Hoisington, Himanshu Gangal ... Dorit Ron
Novel function of Prosapip1, a scaffolding protein highly expressed in the hippocampus, in maintaining postsynaptic density integrity and plays a vital role in synaptic plasticity, learning, and memory.
Multi-omics analyses reveal redundant functions of yeast mRNA decapping activators Scd6 and Edc3 in facilitating recruitment of helicase Dhh1 and accelerating degradation of transcripts required for respiration in glucose-replete cells.
A comparative analysis of genome-wide seasonal gene expression dynamics across four forest tree species revealed that a shared 'molecular calendar' emerges in winter, constraining gene expression evolution and potentially limiting temporal niche partitioning and species divergence in seasonal environments.
Mitochondrial remodeling, ROS-dependent signaling, and diverse environmental and physiological cues underlie the initiation and persistence of locomotory activity of C. elegans in toxic H2S.
A deep generative approach learns the translation from neurons’ electrophysiological recordings to the biophysical parameters of neuron models, assisting in the development of a detailed nervous system model.
