Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Neuroscience

    The self-interest of adolescents overrules cooperation in social dilemmas

    Xiaoyan Wu, Hongyu Fu ... Chao Liu
    Adolescents value reciprocity less than adults, limiting cooperation despite intact learning about others’ behavior.
    1. Neuroscience

    Human exploration strategically balances approaching and avoiding uncertainty

    Yaniv Abir, Michael Neil Shadlen, Daphna Shohamy
    Strategic avoidance of uncertainty emerges under high cognitive demands, enabling faster decisions without impairing learning.
    1. Immunology and Inflammation

    Nociceptor neurons control pollution-mediated neutrophilic asthma

    Jo-Chiao Wang, Amelia Kulle ... Sebastien Talbot
    Air pollution activates macrophage-derived artemin, sensitizing TRPA1 nociceptors to drive neutrophilic asthma, revealing new therapeutic targets for refractory airway inflammation.
    1. Neuroscience

    Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons

    Malin Schmidt, Anne Hoffrichter ... Philipp Koch
    Psilocin induces a durable neuroplastic state in human cortical neurons by enhancing BDNF signaling, neurite complexity, synaptogenesis, and synaptic network activity through 5-HT2A receptor-dependent mechanisms.
    1. Chromosomes and Gene Expression

    UV irradiation alters TFAM binding specificity and compaction of DNA

    Dillon E King, Emily E Beard ... Joel Meyer
    Independent experimental approaches demonstrate changes in TFAM binding to UVC-irradiated DNA, providing a potential mechanism for DNA damage sensing in the mitochondria.
    1. Cancer Biology
    2. Cell Biology

    Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

    Qi Zhang, Yunfeng Wang ... Shaowei Zhao
    Uev1A and APC/C degrade CycA to counteract oncogenic Ras, thereby protecting against cell death in polyploid Drosophila nurse cells and suppressing overgrowth in diploid germline and human colorectal tumor cells.
    1. Biochemistry and Chemical Biology

    Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    A DNA origami nanospring introduces a force-sensing technology that enables measurement of motor protein stall forces without optical trapping, detecting force changes in kinesin KIF1A and its disease-related mutants.
    1. Developmental Biology

    Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans

    Marilina Raices, Fabiola Balmir ... Judith L Yanowitz
    HIM-5 emerges as a central scaffold that coordinates SPO-11 accessory complexes to control different aspects of meiotic DNA double-strand breaks, ensuring robust crossover formation on autosomes and the X chromosome.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Human genetic ancestry, Mycobacterium tuberculosis diversity, and tuberculosis disease severity in Dar es Salaam, Tanzania

    Michaela Zwyer, Zhi Ming Xu ... Daniela Brites
    The severity of active tuberculosis in a high-burden population is not explained by host or pathogen genetic variation, suggesting a dominant role for social and environmental factors.