Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Cell Biology
    2. Medicine

    Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle

    Yibo Fan, Senuri De Silva ... Thiruma V Arumugam
    A multi-tissue proteomic atlas uncovers the shared and distinct molecular signatures of metabolic flexibility induced by intermittent fasting.
    1. Physics of Living Systems

    Fragmentation and aggregation of cyanobacterial colonies

    Yuri Z Sinzato, Robert Uittenbogaard ... Maziyar Jalaal
    Flow experiments show how the formation of cyanobacterial colonies is driven by cell division, aggregation, and fragmentation under different hydrodynamic conditions.
    1. Cancer Biology

    PTEN restrains SHH medulloblastoma growth through cell autonomous and nonautonomous mechanisms

    Zhimin Lao, Salsabiel El Nagar ... Alexandra L Joyner
    Homozygous but not heterozygous loss of Pten in sporadic mouse models of SHH-medulloblastoma greatly accelerates tumor formation, not metastasis, through increased survival of differentiated cells and possibly decreased infiltrating macrophages.
    1. Developmental Biology

    Cdhr1a and pcdh15b may link photoreceptor outer segments with calyceal processes revealing a potential mechanism for cone-rod dystrophy

    Meet K Patel, Warlen Pereira Piedade, Jakub K Famulski
    Zebrafish cone photoreceptor outer segment integrity may be regulated by the interactions between the outer segments and calyceal processes mediated by retinal cadherins cdhr1a and pcdh15b.
    1. Neuroscience

    Modality-agnostic decoding of vision and language from fMRI

    Mitja Nikolaus, Milad Mozafari ... Rufin VanRullen
    Modality-agnostic decoders leverage modality-invariant representations in human subjects' brain activity to predict stimuli irrespective of their modality (image, text, mental imagery).
    1. Computational and Systems Biology

    Single-mRNA imaging and modeling reveal coupled translation initiation and elongation rates

    Irene Lamberti, Jeffrey A Chao ... Felix Naef
    Mammalian cells dynamically scale translation initiation to match distinct elongation rates, preventing ribosome crowding and preserving protein synthesis homeostasis across diverse transcripts.
    1. Immunology and Inflammation

    Heat shock factor regulation of antimicrobial peptides expression suggests a conserved defense mechanism induced by febrile temperature in arthropods

    Bang Xiao, Shihan Chen ... Chaozheng Li
    Febrile temperatures enhance antiviral immunity through heat shock factor-dependent antimicrobial peptides across arthropods.
    1. Ecology

    Geomagnetic and visual cues guide seasonal migratory orientation in the nocturnal fall armyworm, the world’s most invasive insect

    Yi-Bo Ma, Guijun Wan ... Gao Hu
    Behavioral evidence demonstrates that geomagnetic and visual cues are integrated to guide nocturnal migratory insects.
    1. Microbiology and Infectious Disease

    Global transcription factors analyses reveal hierarchy and synergism of regulatory networks and master virulence regulators in Pseudomonas aeruginosa

    Jiadai Huang, Yue Sun ... Xin Deng
    Systematic ChIP-seq profiling of 172 transcription factors in Pseudomonas aeruginosa reveals a hierarchical regulatory architecture governing virulence and establishes a searchable database to guide antimicrobial drug discovery.
    1. Neuroscience

    Endogenous precision of the number sense

    Arthur Prat-Carrabin, Michael Woodford
    A theory of efficient coding wherein the precision of representations is endogenous, task-dependent, and prior-dependent predicts scaling laws for imprecision and is supported by numerosity perception experiments with humans.