Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Estrogens produced in the teleost brain increase neural sensitivity to testicular androgens by directly stimulating androgen receptor transcription, thereby eliciting male-typical behaviors.
Magdalena Boch, Katrin Karadachka ... Rogier B Mars
A large-scale investigation of carnivoran brain diversity, providing a unified description of folding patterns, their relationship to behaviour and ecology, and the foundation for future investigations of carnivoran neuroecology.
Synthetic ribbon-type active zones are reconstituted in cultured cells using a minimal set of proteins that partially mimic structural and functional features of cochlear inner hair cell active zones.
Mathias Sablé-Meyer, Lucas Benjamin ... Stanislas Dehaene
fMRI and MEG results in adults and children show encoding of abstract geometric regularities in dorsal-parietal, temporal, and frontal regions, pointing to a system for symbolic geometric representation in humans.
Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based epigenome editing.
J Ignacio Gutierrez, Claudia Edgar, Jessica K Tyler
Live imaging analyses in budding yeast reveal that calorie restriction and overexpression of the mRNA binding protein Ssd1 both block deleterious age-dependent iron uptake as a mechanism to extend lifespan.
Linking biological research with disordered-systems modeling, providing new insights into gut microbiome stability, functioning, and their relationship with health.
Lipid imbalance triggered by Snail-driven epithelial–mesenchymal transition creates a cholesterol-dependent vulnerability that can be therapeutically targeted to overcome chemoresistance in cancer.
Giulia Di Bartolomei, Raúl Ortiz ... Peter Scheiffele
An alternative splicing regulator previously implicated in calcium signaling in the heart ensures cell-type-specific mRNA processing of long neuronal mRNAs in the mouse brain.
