Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Psilocin induces a durable neuroplastic state in human cortical neurons by enhancing BDNF signaling, neurite complexity, synaptogenesis, and synaptic network activity through 5-HT2A receptor-dependent mechanisms.
Air pollution activates macrophage-derived artemin, sensitizing TRPA1 nociceptors to drive neutrophilic asthma, revealing new therapeutic targets for refractory airway inflammation.
Independent experimental approaches demonstrate changes in TFAM binding to UVC-irradiated DNA, providing a potential mechanism for DNA damage sensing in the mitochondria.
A DNA origami nanospring introduces a force-sensing technology that enables measurement of motor protein stall forces without optical trapping, detecting force changes in kinesin KIF1A and its disease-related mutants.
Marilina Raices, Fabiola Balmir ... Judith L Yanowitz
HIM-5 emerges as a central scaffold that coordinates SPO-11 accessory complexes to control different aspects of meiotic DNA double-strand breaks, ensuring robust crossover formation on autosomes and the X chromosome.
Uev1A and APC/C degrade CycA to counteract oncogenic Ras, thereby protecting against cell death in polyploid Drosophila nurse cells and suppressing overgrowth in diploid germline and human colorectal tumor cells.
The severity of active tuberculosis in a high-burden population is not explained by host or pathogen genetic variation, suggesting a dominant role for social and environmental factors.
Adam L Kenet, Sooraj Achar ... Grégoire Y Altan-Bonnet
An automated bioluminescent image analysis framework, maRQup, parametrizes tumor dynamics and provides quantitative metrics, enabling large-scale evaluation and optimization of preclinical cancer immunotherapies.
