Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Cell Biology

    Testosterone-induced metabolic changes in seminal vesicle epithelium modify seminal plasma components with potential to improve sperm motility

    Takahiro Yamanaka, Zimo Xiao ... Masayuki Shimada
    Testosterone promotes the conversion of glucose to fatty acids by increasing the expression of ACLY in seminal vesicle epithelial cells, thereby regulating the seminal plasma components.
    1. Developmental Biology

    Extracellular adenosine deamination primes tip organizer development in Dictyostelium

    Pavani Hathi, Baskar Ramamurthy
    Extracellular adenosine deamination by ADGF generates ammonia that directs tip organizer development, revealing a conserved metabolic mechanism linking nucleotide turnover to developmental regulation.
    1. Cancer Biology

    Multi-gradient permutation survival analysis identifies mitosis and immune signatures steadily associated with cancer patient prognosis

    Xinlei Cai, Yi Ye ... Hongbin Ji
    Genes steadily associated with prognosis define conserved mitotic and immune programs that robustly predict cancer patient survival and therapeutic resistance across tumor types.
    1. Plant Biology

    An increase of NPY1 expression leads to inhibitory phosphorylation of PIN-FORMED (PIN) proteins and suppression of pinoid (pid) null mutants

    Michael Mudgett, Zhouxin Shen ... Yunde Zhao
    A cause and impact of PIN-FORMED protein phosphorylation has been revealed.
    1. Microbiology and Infectious Disease

    An in vitro human vessel model to study Neisseria meningitidis colonization and vascular damages

    Léa Pinon, Melanie Chabaud ... Guilllaume Dumenil
    A vessel on a chip microfluidic device recapitulates the main features of meningococcal vascular colonization, providing high time and space microscopy resolution of the infection process in 3D.
    1. Neuroscience

    On CA1 ripple oscillations in rats and the reassessment of asynchronicity evidence

    Robson Scheffer-Teixeira, Adriano BL Tort
    Ripples maintain time-locked occurrence across the septo-temporal axis and hemispheres while showing local phase coupling, revealing a dual mode of synchrony in CA1 network dynamics.
    1. Immunology and Inflammation

    Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

    Sabelo Hadebe, Anca Flavia Savulescu ... Frank Brombacher
    Immunoglobulin M has other functions beyond antibody class switching that have implications in asthma treatment.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Exploiting fluctuations in gene expression to detect causal interactions between genes

    Euan Joly-Smith, Mir Mikdad Talpur ... Andreas Hilfinger
    Analyzing stochastic cell-to-cell variability can potentially reveal causal interactions in gene regulatory networks.
    1. Neuroscience

    Strikingly different neurotransmitter release strategies in dopaminergic subclasses

    Ana Dorrego-Rivas, Darren J Byrne ... Matthew S Grubb
    Different locations of neurotransmitter release sites in axon-bearing and anaxonic olfactory bulb dopaminergic neurons allow self-inhibition only in anaxonic cells, showing how polarity differences create separate functional roles in sensory processing.
    1. Physics of Living Systems

    Postural adaptations may contribute to the unique locomotor energetics seen in hopping kangaroos

    Lauren Thornton, Taylor Dick ... Christofer J Clemente
    Postural adjustments that reduce ankle leverage in kangaroos enhance tendon stress and elastic energy storage at higher speeds, providing energetic efficiency during hopping but potentially constraining the maximum size achievable by large species.