Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multiple modes of cholesterol translocation in the human Smoothened receptor

    Prateek D Bansal, Maia Kinnebrew ... Diwakar Shukla
    Multiple competing hypotheses concerning the cholesterol accessibility of oncoprotein Smoothened are quantitatively assessed and experimentally validated, showing that cholesterol takes two pathways from either membrane leaflet to the binding sites.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

    Luke J Dillard, Gina Calabrese ... Charles Farber
    Single-cell transcriptomics data from mouse bone-relevant cells was used to inform human bone mineral density genome-wide association studies and prioritize genetic targets with potential causal roles in the development of osteoporosis.
    1. Developmental Biology

    Mouse germline cysts contain a fusome-like structure that mediates oocyte development

    Madhulika Pathak, Allan C Spradling
    Mammalian oocytes utilize a conserved combination of cell cycle control, cytoskeletal organization, and polarity pathways that are fundamentally shared with other vertebrates and invertebrates.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins

    Roberta Carloni, Tadhg Devlin ... Robin C Allshire
    Synthetic proteins designed to bind specific repetitive DNA sequences in the Trypanosoma brucei genome allow the identification of proteins enriched over different DNA elements.
    1. Cell Biology

    Large-scale identification of plasma membrane repair proteins revealed spatiotemporal cellular responses to plasma membrane damage

    Yuta Yamazaki, Keiko Kono
    Proteome-scale visual screening in budding yeast provides a functional catalog of plasma membrane repair proteins and reveals the coordinated cellular responses at the bud tip and the damage site.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

    Alan Monziani, Juan Pablo Unfried ... Igor Ulitsky
    EPB41L4A-AS1, a highly expressed snoRNA host long noncoding RNA, has multiple functions, positive regulation in cis of the EPB41L4A gene and a trans-acting role in supporting proper nucleolar biology.
    1. Neuroscience

    Peripheral anatomy and central connectivity of proprioceptive sensory neurons in the Drosophila wing

    Ellen Lesser, Anthony J Moussa, John C Tuthill
    Comprehensive mapping of wing sensory neurons in Drosophila reveals that some proprioceptors make direct connections onto flight steering motor neurons, enabling rapid feedback control during flight.
    1. Neuroscience

    Movie reconstruction from mouse visual cortex activity

    Joel Bauer, Troy W Margrie, Claudia Clopath
    Naturalistic movie reconstruction from mouse visual cortex activity achieves high spatial and temporal fidelity.
    1. Developmental Biology
    2. Genetics and Genomics

    Nup107 is a crucial regulator of torso-mediated metamorphic transition in Drosophila melanogaster

    Jyotsna Kawadkar, Pradyumna Ajit Joshi, Ram Kumar Mishra
    Y-complex nucleoporin, Nup107, can regulate ecdysone production by affecting the transcription of Halloween genes and levels of RTK receptor, torso, for the metamorphic transition from larva to pupa.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Automated genome mining predicts structural diversity and taxonomic distribution of peptide metallophores across bacteria

    Zachary L Reitz, Bita Pourmohsenin ... Marnix H Medema
    Automated detection of metallophore biosynthesis reveals that metal-chelating non-ribosomal peptides are widespread, chemically diverse, and deeply rooted in bacterial evolution.