Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Morgane Vandendoren, Jason G Landen ... Adam Nelson
Oxytocin neurons couple physiological warming to behavioral arousal, revealing a homeostatic mechanism that coordinates transitions between low- and high-energy states.
Simulation-based inference predicts putative circuit mechanisms of hyperexcitability in a phenomenological microcircuit simulator with more than 30 free intrinsic and synaptic parameters.
The interaction of important signaling pathway members identified through in silico and in vitro approaches provides a model that suggests local receptor multimerization through bridging functions of various ligands.
A large-scale convergence gradient and a fine-scale divergence gradient in cortical architecture capture visual hierarchy, areal boundaries, and behavior, uncovering an undescribed retinotopic representation in anterior temporal cortex.
The supraspinal system of larval zebrafish has been described, uncovering spinal projections from the telencephalon, mesencephalon, and rhombencephalon, as well as numerous motor and neuromodulatory nuclei conserved with mammals.
Mapping the molecular interactions between polymyxins and hPepT2 enables rational design of safer lipopeptide antibiotics with reduced renal toxicity while retaining antibacterial activity.
In the presence of emulated cone loss, eye movements are used to gather and integrate information, leading to improved letter acuity compared to a non-moving condition.
Ishmael Nii Ayibontey Tagoe, Amanpreet Kaur ... Malini Raghavan
Endoplasmic reticulum and cytosolic calcium levels, and store-operated calcium entry, are comparable in calreticulin-deficient cells rescued with either wild-type calreticulin or the myeloproliferative neoplasm-linked Del52 mutant.
Sung Hoon Cho, Shawna K Brookens ... Mark R Boothby
Genetic and biochemical analyses reveal a way to overcome the metabolic flexibility of B cells and undermine their cytokine receptor signaling and differentiation into antibody-secreting cells, therapeutic targets in systemic lupus erythematosus (SLE).
