Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.
In vision-based flight control of hummingbird hawkmoths, the visual field partitions by natural cue prevalence into an optic flow and dorsal directional pathway, which integrate according to their relevance for flight safety.
Genetic analyses of rare non-mosaic females define X-inactivation status for 380 genes and uncover widespread X-chromosome skewing in the general population, providing insights into sex-biased traits and X-linked disease expression.
The cryo-EM structures of a pentameric ligand-gated ion channel in liposomes, an environment that supports ion channel function, are different than structures in lipid nanodiscs.
The architectures of human PIEZO1 and its slow-inactivating channelopathy mutants with or without its auxiliary subunit MDFIC reveal the inactivation mechanism of PIEZO channels.
Andrew M Shelton, David K Oliver ... Adam Max Packer
The claustrum integrates and redistributes sensory and frontal cortical inputs across distinct neural modules to enhance sensitivity to multimodal stimuli.
Theoretical modeling uncovers an unusual acceleration in microbial growth following osmotic shock, driven by the coordinated regulation of osmolyte production and cell-wall synthesis.
Changes in the pericyte pool after stroke affect the restoration of the blood-brain barrier function and brain self-repair, and offer a new approach to therapy.
Changli Zhang, Martha Elena Diaz-Hernandez ... Hicham Drissi
PDGF mitigated cellular senescence in human intervertebral disc by modulating cell cycle, inflammation, and mitochondria function, offering a potential strategy for combating age-induced disc degeneration.
