Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.
Julian JA Hoving, Elizabeth Harford-Wright ... Alison C Lloyd
N-cadherin and Slit2/3/Robo interactions provide the outward force to drive collective Schwann cell migration during nerve regeneration, identifying a dual role for N-cadherin in both adhesion and repulsion processes during Schwann cell collective migration.
Christian Galicia, Giambattista Guaitoli ... Wim Versées
Conformation-specific nanobodies enable to capture and solve the first GTP-bound active structure of a bacterial homolog of the Parkinson-associated LRRK2 protein, providing insights into the activation mechanism of these proteins.
AlphaFold-Multimer was used to investigate extracellular protein interactions involved in mammalian egg-sperm recognition, suggesting a putative pentameric complex that includes TMEM81, a sperm protein not previously involved in gamete recognition.
An individual-based model framework of sub-exponentially growing replicator systems suggests that parabolic dynamics could have been able to maintain genetic diversity and circumvent the error threshold problem during early evolution.
Marcos Moreno-Aguilera, Alba M Neher ... Carme Gallego
KIS, a kinase upregulated in the developmental brain, phosphorylates the PTBP2 splicing complex and modulates alternative exon usage for proper synaptic spine emergence and maturation.
Sleep-encoded vocabulary influences awake decision-making 36 hr later, particularly when targeting the vocabulary to slow-wave troughs, which suggests that unconscious episodic memory formation during deep sleep is possible.
Sangeetha Kandoi, Cassandra Martinez ... Deepak A Lamba
Stem cell-derived retinal organoids are a useful tool to understand the pathobiology of devastating retinal degenerations and can aid to identify and validate therapeutics to promote rescue.
Analysis of mice lacking the precursor for irisin, FNDC5, provides evidence for a sex-specific role of irisin in calcium release from bone due to osteocytic osteolysis.
