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    1. Medicine

    Less than one in ten Phase III clinical trials are ever cited at the point-of-care

    A decade-long analysis reveals potential bottlenecks in the pathway of clinical research into medical practice.
    1. Medicine

    Study supports evidence ivermectin is ineffective at treating COVID-19

    PLATCOV, a platform to assess the effectiveness of drugs against COVID-19, suggests that ivermectin has no significant antiviral activity against SARS-CoV-2.
    1. Evolutionary Biology

    Multiple mutations may help Omicron variant escape antibodies

    Just one or two mutations with strong effects, or an accumulation of mutations with small effects, may help the Omicron variant of SARS-CoV-2 dodge the immune system or antibody-based therapies.
  1. Biophysics Colab shifting to full ‘Publish, Review, Curate’ service for authors

    The expanded service will provide biophysicists with a new way of validating their research.
  2. Media Coverage: January roundup of eLife papers in the news

    High-profile news coverage that eLife papers generated in January 2023, including The Washington Post, The New York Times and Earth.com.
    1. Neuroscience

    Rats trade initial rewards for long-term learning opportunities

    When deciding on responses to a new stimulus, slower initial response times can maximise long-term reward through learning.
    1. Epidemiology and Global Health
    2. Medicine

    Analysis of cancer treatment reveals need for standardised methods to measure waiting times

    An analysis of cancer diagnosis and treatment highlights inconsistencies in the way lag times are calculated and suggests more standardised approaches are needed.
    1. Ecology
    2. Epidemiology and Global Health

    Antibiotic consumption is currently not the main driver of aminoglycoside resistance spread, study suggests

    Drug resistance to aminoglycosides, a class of antibiotics, may be driven more by exchanges between ecosystems than by drug consumption.
    1. Genetics and Genomics

    Oral bacteria may increase heart disease risk

    Infection with a common bacteria linked with periodontal disease, oral cancers, and bad breath may cause a small increase in the risk of cardiovascular disease.
    1. Cancer Biology
    2. Medicine

    One in two cancer patients may develop long COVID, with risk higher in women

    A follow-up study of cancer patients after COVID-19 suggests that one in two experienced long COVID, but few required hospital admission and most could be managed as outpatients.