A large-scale systematic investigation to replicate high-impact, preclinical cancer biology experiments identified barriers to conducting replications and observed weaker evidence for the findings compared with the original experiments. Unnecessary friction in the research process may be slowing the advancement of knowledge, solutions and treatments.
Novel software for grouping immunological T-cell receptors may enable the identification of shared patterns that could be used to determine if a person has previously been infected or vaccinated against a given pathogen.
A study provides evidence to support the theory that stronger selection on males allows them to purge the population of genetic mutations that reduce survival fitness.
New lower back fossils are the “missing link” that settles a decades-old debate proving early hominins used their upper limbs to climb like apes, and their lower limbs to walk like humans.
Scientists have shed new light on how insulin is released from beta cells in the pancreas, with potential implications for understanding more about what happens in diseases such as diabetes.
A study using machine learning techniques suggests that maintaining an optimal range of blood pressure control during surgical repair of spinal injuries may improve patient outcomes.
A mathematical model that uses information from routine scans or tissue biopsy analysis may help predict the effectiveness of immunotherapy treatment for individual patients.
