873 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Connectivity map of bipolar cells and photoreceptors in the mouse retina

    Christian Behrens, Timm Schubert ... Philipp Berens
    A quantitative analysis of the connectivity between photoreceptors and bipolar cells in the mouse retina based on electron microscopy data yields exceptions from established rules of outer retinal connectivity.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Cis-regulatory basis of sister cell type divergence in the vertebrate retina

    Daniel P Murphy, Andrew EO Hughes ... Joseph C Corbo
    While photoreceptor and bipolar cells exhibit very similar cis-regulatory grammars, subtle differences in homeodomain motif enrichment represent a key distinction driving the divergence in their transcriptomes.
    1. Neuroscience

    GABAA presynaptic inhibition regulates the gain and kinetics of retinal output neurons

    Jenna Nagy, Briana Ebbinghaus ... Raunak Sinha
    Elimination of GABAA receptors from the axon terminals of specific retinal bipolar cell types alters the sensitivity and kinetics of retinal output.
    1. Neuroscience

    The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges

    Pierre-Luc Rochon, Catherine Theriault ... Arjun Krishnaswamy
    A novel retinal ganglion cell requires a cell adhesion molecule to grow its dendrites, collect synaptic inputs, and become selective to edges placed in its receptive field.
    1. Evolutionary Biology
    2. Neuroscience

    True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field

    Francisco M Nadal-Nicolás, Vincent P Kunze ... Wei Li
    Unique 'true' S-cone and S-cone bipolar cell distribution patterns in the mouse retina are previously unappreciated anatomical features that support enhanced short-wavelength signaling for color detection above horizon.
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    1. Computational and Systems Biology
    2. Neuroscience

    Mapping nonlinear receptive field structure in primate retina at single cone resolution

    Jeremy Freeman, Greg D Field ... EJ Chichilnisky
    Multi-electrode recordings and modeling are combined to reveal the transformations of signals from cones to bipolar cells and then to ganglion cells within the primate retina.
    1. Developmental Biology
    2. Evolutionary Biology

    Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network

    Joaquín Letelier, Lorena Buono ... Juan R Martínez-Morales
    Depletion of vsx genes in zebrafish confirms a conserved role in bipolar cells specification across vertebrates, but do not interfere with the formation of the neural retina domain, which reveal an unexpected robustness of the genetic network sustaining the retina.
    1. Neuroscience

    Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells

    Yuwei Cui, Yanbin V Wang ... Daniel A Butts
    The convergence of two visual pathways at the level of retinal bipolar cells accounts for key features of ganglion cell responses.
    1. Neuroscience

    Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision

    Silvia JH Park, Evan E Lieberman ... Joshua H Singer
    Anatomical and physiological analyses identified an inhibitory interneuron that is an integral part of the rod bipolar cell pathway, the circuit for night vision, of the mammalian retina.
    1. Neuroscience

    Cross-synaptic synchrony and transmission of signal and noise across the mouse retina

    William N Grimes, Mrinalini Hoon ... Fred Rieke
    Cells within the retina synchronize transmitter release across their output synapses in the dark, reducing the impact of noise generated at these synapses and allowing light-dependent signals to be transmitted with minimal added synaptic noise.

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