Mitochondrial dysfunction in neural stem cells and brain tumour cells decreases proliferation and affects the generation of neuronal diversity and tumour heterogeneity.
Jean M Mulcahy Levy, Shadi Zahedi ... Andrew Thorburn
Pre-clinical and patient data show that inhibition of autophagy with an approved, inexpensive, well-tolerated drug can overcome resistance to BRAFV600E inhibition in multiple brain tumor subtypes with different resistance mechanisms.
Nerve tracing and behavioral studies in tumor-bearing mice together with transcriptional and functional analysis reveal cancer-induced central and peripheral neuronal alterations that influence behavior.
Pre-neoplastic cells in the brain release SDF1, which mediates an immediate infiltration of macrophages that differentiate into microglia-like cells and promote proliferation of pre-neoplastic cells.
Whole-brain radiotherapy, but not glioma growth in distal region from the hippocampus, results in impaired recognition memory, which can be prevented by CSF-1R inhibitor-mediated microglia depletion.
Nalin Leelatian, Justine Sinnaeve ... Jonathan M Irish
A new automated and unsupervised algorithm, Risk Assessment Population IDentification, identifies risk-stratifying cells in single cell datasets with robust statistical and biological validation.
A regionally resolved single-cell RNA-sequencing analysis of GBM-associated leukocytes reveals distinct activation states of the main immune populations between tumor center, peripheral infiltration zone and blood.