The estimation of individual genetic effects across different contexts can be boiled down to a bias-variance trade-off, yet for complex traits, the joint consideration of numerous causal effects alters this trade-off.

Predictable patterns of fitness evolution observed in microbial evolution experiments can emerge generically as a consequence of widespread epistatic interactions between mutations.

A bulk barcoded quantitative trait locus approach increases the power and resolution of genotype-phenotype mapping in yeast, revealing that the genetic architecture of 18 complex traits is highly polygenic, and is characterized by widespread epistatic interactions and pleiotropic effects.

Genetic and functional studies reveal a previously unrecognized role for a transmembrane protein in glomerular filtration barrier function.

A novel statistical framework and approach using sibling phenotype pairs allows inference of genetic architecture in the tails of complex traits to be made without genetic data.

A powerful sequencing approach is used to elucidate the genetic basis of a complex organismal trait, and members of the irld gene family that affect starvation resistance are identified.

The DGRPool web tool aggregates phenotyping data from the Drosophila Genetic Reference Panel, streamlining genetic association studies and offering new insights into genetic and phenotypic variation in complex traits.

By comparing gene expression in people before and after they received the influenza vaccine, researchers were able to identify genes that contribute to differences in individual responses to vaccination.

Many prior signals of polygenic adaptation on human height do not replicate in the UK Biobank.

Across urate, IGF-1, and testosterone, thousands of dispersed variants contribute to heritability, while previously characterized core pathways are highly enriched for associations and reveal feedback mechanisms governing serum biomarker levels.