A comprehensive molecular interrogation of CREB5 interactions identified changes in protein and chromatin interactions of FOXA1 that promoted therapy resistance in prostate cancer cells.

The transcription factor CrebB mediates long-term memory formation in different neurons within the mushroom body learning circuit, including mushroom body intrinsic and output neurons but not dopaminergic input neurons.

A single protein catalyzes site-specific DNA recombination upon blue-light illumination.

Through an image and behavioral screen based on MiMIC technology, we identified a novel kinase, CG11221 renamed Meng-Po (MP), and showed that flies that lack MP in mushroom bodies can learn but cannot remember as MP is required for the protein stability of CREBB.

The prokaryotic actin homologue MreB forms antiparallel double filaments in vitro and in vivo, an architecture that is unprecedented among the actin family of proteins.

Targeting aberrant CRTC-CREB activation blocks the growth of LKB1-inactivated lung cancer.

First 3D-structure and first observation of organized protofilaments of MreB from a Gram-positive bacterium, suggesting a model where ATP drives the formation of dynamic pairs of MreB protofilaments on a lipid surface.

Radial plant growth produces large parts of terrestrial biomass and can be computationally simulated with the help of an instructive framework of intercellular communication loops.

Behavioral, biochemical, and biophysical analyses show that age-related memory deficits can be rescued by directly overexpressing wild-type CREB.

Unbiased single-cell RNAseq data analysis combined with mouse genetic approaches reveal that TGF-β signaling and perimysial-specific regulators may cooperatively define perimysial-to-myogenic signals in regulating pharyngeal myogenesis.