16,732 results found
    1. Physics of Living Systems

    In-line swimming dynamics revealed by fish interacting with a robotic mechanism

    Robin Thandiackal, George Lauder
    Fish in the thrust wake of a flapping foil reduce tail-beat frequencies, synchronize with oncoming vortices, and swim energetically more efficiently.
    1. Cell Biology
    2. Computational and Systems Biology

    Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response

    Rania Garde, Abhyudai Singh ... David Pincus
    The chaperones Hsp70 and Sis1 collaborate to repress the heat shock response and are both transcriptional targets of the heat shock response, yet only Hsp70 acts as a negative feedback regulator of the heat shock response.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structures of human dynein in complex with the lissencephaly 1 protein, LIS1

    Janice M Reimer, Morgan E DeSantis ... Andres E Leschziner
    Structures of human cytoplasmic dynein-1 bound to its regulator LIS1 reveal the interfaces involved in forming the complex and provide a context for disease-linked mutations.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for cytoplasmic dynein-1 regulation by Lis1

    John P Gillies, Janice M Reimer ... Samara L Reck-Peterson
    A 3.1 Å structure of cytoplasmic dynein-1 in complex with its regulator Lis1 reveals the interfaces between dynein and Lis1, all of which are important for dynein function in vitro and in vivo.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Lis1 regulates dynein by sterically blocking its mechanochemical cycle

    Katerina Toropova, Sirui Zou ... Andres E Leschziner
    Structural and functional studies reveal how a ubiquitous regulator of dynein keeps the microtubule-based motor in a persistent track-bound state.
    1. Genetics and Genomics

    High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species

    Molly Schumer, Rongfeng Cui ... Peter Andolfatto
    Genetic incompatibilities are common and widely distributed throughout the genomes of swordtail fish, and prevent the regions of the genome around them from being exchanged between different species.
    1. Physics of Living Systems

    Hydrodynamic model of fish orientation in a channel flow

    Maurizio Porfiri, Peng Zhang, Sean D Peterson
    A hydrodynamic model of fish swimming in a channel predicts a critical flow speed for fish to successfully swim against a flow, unveiling a passive mechanism for rheotaxis to emerge without access to any sensory information.
    1. Neuroscience

    Detection of transient synchrony across oscillating receptors by the central electrosensory system of mormyrid fish

    Alejandro Vélez, Bruce A Carlson
    Building on previous work (Baker et al., 2015), further evidence is reported for a novel mechanism for sensory coding based on the detection of oscillatory synchrony among peripheral receptors.
    1. Developmental Biology

    A scalable and tunable platform for functional interrogation of peptide hormones in fish

    Eitan Moses, Roman Franek, Itamar Harel
    A novel in vivo strategy for reversible, multiplexed control of circulating hormone expression levels, achieved by combining genome-editing and intramuscular electroporation of fluorescently tagged hormones in the naturally short-lived turquoise killifish.
    1. Ecology

    5α-cyprinol sulfate, a bile salt from fish, induces diel vertical migration in Daphnia

    Meike Anika Hahn, Christoph Effertz ... Eric von Elert
    A fish-derived bile salt was shown to act as interspecific infochemical, inducing the widespread predator avoidance behavior diel vertical migration at picomolar concentrations in freshwater zooplankton of the genus Daphnia.

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