11,809 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia

    Fransky Hantelys, Anne-Claire Godet ... Anne-Catherine Prats
    In mouse cardiomyocytes, (lymph)angiogenic growth factors are induced during early hypoxia by a translational mechanism involving a new IRES trans-acting factor, vasohibin-1.
    1. Developmental Biology
    2. Genetics and Genomics

    CRISPR/Cas9 and active genetics-based trans-species replacement of the endogenous Drosophila kni-L2 CRM reveals unexpected complexity

    Xiang-Ru Shannon Xu, Valentino Matteo Gantz ... Ethan Bier
    Dissection of a cis-regulatory element (CRM) in its native chromosomal context using CRISPR/Cas9 editing and novel 'Active Genetics' reveals new features of CRM function and insights into how such regulatory elements change during evolution.
    1. Structural Biology and Molecular Biophysics

    Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

    Timothy Grant, Nikolaus Grigorieff
    The resolution of electron cryo-microscopy can be improved by using optimal exposure values to filter video frames.
    1. Neuroscience

    Parallel processing by distinct classes of principal neurons in the olfactory cortex

    Shivathmihai Nagappan, Kevin M Franks
    In vivo recordings from identified cell classes in the olfactory cortex of a novel transgenic mouse reveal that distinct classes of principal neurons operate largely in parallel and differentially process odor information.
    1. Neuroscience

    Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states

    Kevin A Bolding, Shivathmihai Nagappan ... Kevin M Franks
    Intracortical circuits in mouse olfactory cortex stabilize odor-evoked activity patterns when upstream inputs, from olfactory bulb, become degraded under anesthesia.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci

    Reza K Hammond, Matthew C Pahl ... Struan FA Grant
    By integrating GWAS data sets with ATAC-seq and promoter-focused Capture C data, one can uncover further loci beyond those that reach genome-wide significance (p<5x10-8).
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Long non-coding RNA Neat1 and paraspeckle components are translational regulators in hypoxia

    Anne-Claire Godet, Emilie Roussel ... Anne-Catherine Prats
    LncRNA Neat1, with paraspeckle proteins, controls translational induction of (lymph)angiogenic and cardioprotective factors by the IRES-dependent mechanism in mouse cardiomyocytes submitted to hypoxia.
    1. Genetics and Genomics
    2. Neuroscience

    A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia

    Nathan G Skene, Marcia Roy, Seth GN Grant
    A genetic program controlling brain genes across the lifespan specifies a calendar of changes in cells, synapses and behavioural genes thereby timing the onset of mental illnesses which arise in young adults.
    1. Stem Cells and Regenerative Medicine

    A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

    Henrik Renner, Martha Grabos ... Jan M Bruder
    Automated liquid handling, whole mount staining, and clearing allow unbiased 3D quantitation of cell markers in human neural organoids with diameters of up to 1 mm at the single-cell level.
    1. Plant Biology

    Lipid transfer from plants to arbuscular mycorrhiza fungi

    Andreas Keymer, Priya Pimprikar ... Caroline Gutjahr
    Identification of two arbuscular mycorrhiza-specific lipid biosynthesis mutants and fatty acid transfer experiments reveal that host plant lipids are transferred to symbiotic fungi and needed for their development.

Refine your results by:

Type
Research categories