Fabien Sindikubwabo, Shuai Ding ... Mohamed-ali Hakimi
A versatile acetylation-methylation switch at lysine 31 on the lateral surface of histone H4 contributes to chromatin structure in apicomplexan parasites.
The structure of Bre1’s Rad6-binding domain in complex with Rad6 provides insights into the Bre1 and Rad6-catalyzed histone protein H2B mono-ubiquitination.
Emma A Morrison, Samuel Bowerman ... Catherine A Musselman
The BPTF PHD finger is inhibited from binding the methylated H3 tails in the context of the nucleosome due to their robust interaction with the nucleosomal DNA, which can be modulated by additional histone PTMs.
Biochemical approaches reveal that an epigenetic histone deacetylase complex called CoREST is slow to deacetylate histone H3 lysine-14 in nucleosomes, and this inhibits demethylation of histone H3 lysine-4 by the CoREST complex.
A previously uncharacterized type of bivalent chromatin plays an important role controlling the timely induction of genes involved in making a potent defense metabolite upon a pathogen signal in Arabidopsis.
Xiao-Yong Li, Melissa M Harrison ... Michael B Eisen
Drosophila melanogaster embryos undergo a dramatic genomic transformation in the hour preceding gastrulation, as thousands of promoters and regulatory regions become biochemically distinct before they become active.
Michael P Meers, Telmo Henriques ... A Gregory Matera
Post-translational modification of histone H3K36 is not required to suppress cryptic transcription initiation or to include alternative exons in Drosophila; instead it promotes expression of active genes by stimulating polyadenylation.