14,316 results found
    1. Genetics and Genomics

    Genome-wide association study in quinoa reveals selection pattern typical for crops with a short breeding history

    Dilan SR Patiranage, Elodie Rey ... Christian Jung
    A new insight into quinoa diversity enables sequence-based breeding and functional genomics.
    1. Neuroscience

    Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys

    Norihiro Takakuwa, Rikako Kato ... Tadashi Isa
    The subcortical visual pathway through the midbrain superior colliculus is responsible for visually evoked Pavlovian conditioning and dopamine neuron responses with predicted value in monkeys, which remained after lesioning V1.
    1. Neuroscience

    The shared and unique neural correlates of personal semantic, general semantic, and episodic memory

    Annick FN Tanguay, Daniela J Palombo ... Louis Renoult
    Four types of declarative memory rely on different weightings of similar component processes, according to fMRI and subjective ratings.
    1. Immunology and Inflammation

    CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance

    Yu Li, Pablo Guaman Tipan ... Lauren IR Ehrlich
    Two-photon microscopy, combined with chemotaxis assays, synchronized thymocyte selection studies, and flow cytometry analyses, reveal that CCR4 and CCR7 promote medullary entry and central tolerance of immature and mature post-positive selection thymocyte subsets, respectively, with distinct outcomes for central tolerance.
    1. Developmental Biology
    2. Genetics and Genomics

    miR-124 controls male reproductive success in Drosophila

    Ruifen Weng, Jacqueline SR Chin ... Stephen M Cohen
    A small RNA molecule called miR-124 controls pheromone production and sexual behaviour in Drosophila by regulating sex-specific gene expression in males.
    1. Cancer Biology
    2. Cell Biology

    GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

    Ricardo A Cordova, Jagannath Misra ... Kirk A Staschke
    The ISR kinase GCN2 is critical for maintaining tumor amino acid levels to facilitate growth, suggesting a novel therapeutic strategy for the treatment of prostate cancer by inducing starvation for essential amino acids.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection

    Magdalena Steinrueck, Călin C Guet
    Experimental evolution reveals how adaptation by increased expression of a gene depends on a combination of simple genetic properties of the gene's neighbors on the DNA.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Zygotic pioneer factor activity of Odd-paired/Zic is necessary for late function of the Drosophila segmentation network

    Isabella V Soluri, Lauren M Zumerling ... Shelby A Blythe
    Mechanisms for shaping the chromatin accessibility landscape operate during development to regulate how embryonic patterning information is interpreted at the level of gene regulatory networks.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

    Yosuke Yoneyama, Peter Lanzerstorfer ... Shin-Ichiro Takahashi
    IRS-1, a canonical signaling mediator of IGF-I receptor, serves as an endocytic regulator of IGF-I receptor to facilitate the sustained IGF signaling.
    1. Neuroscience

    Spatial sampling in human visual cortex is modulated by both spatial and feature-based attention

    Daniel Marten van Es, Jan Theeuwes, Tomas Knapen
    The sampling of visual space is not only warped by attention towards locations but also depends on attended features.

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