13,183 results found
    1. Immunology and Inflammation

    Single-cell transcriptome reveals the novel role of T-bet in suppressing the immature NK gene signature

    Chao Yang, Jason R Siebert ... Subramaniam Malarkannan
    T-bet suppresses the expression of immature NK cell-defining genes.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community

    Kevin D'hoe, Stefan Vet ... Jeroen Raes
    Human gut bacteria alter their metabolism in response to each other's presence, which causes their community dynamics to deviate from predictions that are based on mono-culture data.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae

    Rafal Donczew, Steven Hahn
    Yeast bromodomain-containing factors Bdf1/2 offer insights into the biological role of the BET family of transcriptional regulators, which is a promising target in cancer therapy.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing

    Raquel Granell, John A Curtin ... Adnan Custovic
    Using unique data from five longitudinal UK birth cohorts, four distinct subsets of genetic variants were identified as differentially associated across wheezing phenotypes from infancy to adolescence with little evidence of genetic associations spanning across different phenotypes.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism for direct actin force-sensing by α-catenin

    Lin Mei, Santiago Espinosa de los Reyes ... Gregory M Alushin
    Biophysical and structural studies reveal how low piconewton forces across actin enhance binding by the critical cell-cell adhesion protein α-catenin versus its force insensitive homolog vinculin.
    1. Medicine

    Senescent preosteoclast secretome promotes metabolic syndrome associated osteoarthritis through cyclooxygenase 2

    Weiping Su, Guanqiao Liu ... Mei Wan
    Under metabolic syndrome, joint subchondral preosteoclasts acquire a senescence-associated secretome, which causes a rapid structural alteration of subchondral bone and contributes to the development of osteoarthritis.
    1. Ecology

    Meta-analysis challenges a textbook example of status signalling and demonstrates publication bias

    Alfredo Sánchez-Tójar, Shinichi Nakagawa ... Julia Schroeder
    Meta-analysis takes down a textbook example in behavioural and evolutionary ecology, and demonstrates the existence of biases in the current scientific publishing culture.
    1. Neuroscience

    An interactive meta-analysis of MRI biomarkers of myelin

    Matteo Mancini, Agah Karakuzu ... Nikola Stikov
    Most MRI-based myelin biomarkers are not statistically different regarding their relationship with histology.
    1. Evolutionary Biology

    A meta-analysis of the association between male dimorphism and fitness outcomes in humans

    Linda H Lidborg, Catharine Penelope Cross, Lynda G Boothroyd
    While men’s mating success is predicted both by their strength/muscularity, voice pitch, height, and testosterone levels, their reproductive output is only predicted by strength/muscularity.
    1. Neuroscience

    Curvature domains in V4 of macaque monkey

    Jia Ming Hu, Xue Mei Song ... Anna Wang Roe
    There is a systematic functional organization for curvature representation in area V4 where specific curvatures are encoded by unique values (modules) from the set of systematically represented values.

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