3,603 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary dynamics of circular RNAs in primates

    Gabriela Santos-Rodriguez, Irina Voineagu, Robert J Weatheritt
    An analysis of the genomic features that distinguish conserved from species-specific circular RNAs reveals that the expansion of the downstream intron by insertion of retrotransposons stabilizes circular RNAs' production across 30+ millions years of evolution.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Gene autoregulation by 3’ UTR-derived bacterial small RNAs

    Mona Hoyos, Michaela Huber ... Kai Papenfort
    Bacterial small RNAs derived from the 3' untranslated region of an mRNA can serve as autoregulatory elements.
    1. Biochemistry and Chemical Biology

    Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions

    Xi Peng, Francesco Emiliani ... Jeremy Nathans
    Affinity capture of polyribosomes followed by RNAseq(ACAPSeq) is a technique that harnesses massively parallel sequencing to identify protein-protein interactions from any source from which polyribosomes can be purified.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination

    Hongchang Zhao, Stella R Hartono ... Jacqueline Barlow
    Genetic analysis of senataxin and RNase H2-deficient mice reveals that genome stability during class switch recombination and antibody generation can be uncoupled, suggesting a role for R loop metabolism dysfunction in lymphomagenesis in patients without immune deficiency.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking

    Pornchai Kaewsapsak, David Michael Shechner ... Alice Y Ting
    Live-cell nanometer-resolution RNA labeling method enables transcriptome-wide mapping of endogenous RNAs in nuclear, cytosol, ER, and mitochondrial subcompartments.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    RNase III-mediated processing of a trans-acting bacterial sRNA and its cis-encoded antagonist

    Sarah Lauren Svensson, Cynthia Mira Sharma
    Functional characterization of a pair of cis-encoded antisense RNAs reveals a role for RNase III and antisense regulation in the biogenesis and regulatory activity of a bacterial virulence factor-regulating small RNA.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Dissection of affinity captured LINE-1 macromolecular complexes

    Martin S Taylor, Ilya Altukhov ... John LaCava
    The range of molecular forms adopted by L1 retrotransposons reflect a tapestry of lifecycle-permissive and -restrictive host-parasite interactions occurring within cells.
    1. Chromosomes and Gene Expression

    Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling

    Jun Yao, Douglas C Wu ... Alan M Lambowitz
    Human plasma contains protein-protected mRNA fragments, myriad repeat RNAs, and novel intron RNAs, including a family of structured full-length excised introns, some corresponding to mirtron pre-miRNAs and agotrons.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain

    Claudia Scheckel, Elodie Drapeau ... Robert B Darnell
    Neuronal ELAV-like (nELAVL) proteins are associated with non-coding Y RNAs in stressed neurons and in the brains of Alzheimer's disease patients, suggesting a new means of regulatory protein sequestration and mRNA target regulation.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs, and mRNAs in live bacterial cells

    Seongjin Park, Karine Prévost ... Jingyi Fei
    RNA chaperone Hfq dynamically binds various pools of cellular RNAs to execute different regulatory functions.

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