886 results found
    1. Computational and Systems Biology

    Evolution of cell size control is canalized towards adders or sizers by cell cycle structure and selective pressures

    Felix Proulx-Giraldeau, Jan M Skotheim, Paul François
    An evolutionary algorithm is used to build gene networks implementing cell size control, and suggests multiple ways for evolution to first build sizers and turn them into adders depending on evolutionary constraints.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    An optimal regulation of fluxes dictates microbial growth in and out of steady state

    Griffin Chure, Jonas Cremer
    Microbial cells optimally structure their proteomes in order to mutually maximize metabolism and translation, as established by an extensive comparison between data and a low-dimensional model of cellular physiology.
    1. Ecology
    2. Microbiology and Infectious Disease

    Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior

    Caleb N Fischer, Eric P Trautman ... Nichole A Broderick
    Interactions between fungal and bacterial microbiome members alter Drosophila melanogaster's chemical environment, affecting host behavior and survival.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides

    Samuel T Coradetti, Dominic Pinel ... Jeffrey M Skerker
    Using barcoded mutagenesis and a high-throughput genetic screen results in the identification of 150 genes that affect lipid accumulation in a non-model yeast system.
    1. Cell Biology
    2. Computational and Systems Biology

    Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative lifespan

    Simeon Leupold, Georg Hubmann ... Matthias Heinemann
    With replicative age, S. cerevisiae shifts from a fermentative towards an unusual respiratory metabolism, accompanied by a decrease in growth and glucose uptake rate.
    1. Genetics and Genomics

    Unraveling the influences of sequence and position on yeast uORF activity using massively parallel reporter systems and machine learning

    Gemma E May, Christina Akirtava ... Joel McManus
    The regulatory role of thousands of upstream open-reading frames were measured and used to determine the relative influences of sequence, structural, and positional features on translation regulation and nonsense-mediated decay.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation

    Jean-Michel Arbona, Arach Goldar ... Benjamin Audit
    The universal eukaryotic DNA replication kinetics is the consequence of simple physicochemical rules resulting from the localisation of potential replication origins at discrete sites and the diffusion of limiting origin firing factors in the nuclear space.
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    1. Cell Biology

    An aging-independent replicative lifespan in a symmetrically dividing eukaryote

    Eric C Spivey, Stephen K Jones Jr ... Ilya J Finkelstein
    A high throughput, full lifespan microscopic analysis reveals that fission yeast does not age but has a finite replicative lifespan.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Polo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha

    Hiromi Maekawa, Annett Neuner ... Yoshinobu Kaneko
    Cdc5-dependent SPB regulation is linked to delayed cytoplasmic microtubule organization in Ogataea polymorpha.
    1. Cell Biology

    An amphipathic helix in Brl1 is required for nuclear pore complex biogenesis in S. cerevisiae

    Annemarie Kralt, Matthias Wojtynek ... Karsten Weis
    Genetic, proteomic, and structural analyses provide insight into the role of Brl1 during nuclear pore complex biogenesis, suggesting a function in the fusion of outer and inner nuclear membranes.

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