1,947 results found
    1. Developmental Biology
    2. Immunology and Inflammation

    The extraembryonic serosa is a frontier epithelium providing the insect egg with a full-range innate immune response

    Chris G C Jacobs, Herman P Spaink, Maurijn van der Zee
    Contrary to the current perception, insect eggs are very capable of defending themselves against pathogens.
    1. Cell Biology
    2. Developmental Biology

    The beetle amnion and serosa functionally interact as apposed epithelia

    Maarten Hilbrant, Thorsten Horn ... Kristen A Panfilio
    Late morphogenesis of the insect extraembryonic epithelia involves transient formation of a basal-basal bilayer to coordinate the functional contributions of two discrete tissues.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    How lamina-associated polypeptide 1 (LAP1) activates Torsin

    Brian A Sosa, F Esra Demircioglu ... Thomas U Schwartz
    LAP1 adopts an AAA+ like fold that, while unable to bind nucleotide, can enhance ATPase activity in the neighboring TorsinA protomer in an unusual heterohexameric ring, via an arginine finger.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Phasic oxygen dynamics confounds fast choline-sensitive biosensor signals in the brain of behaving rodents

    Ricardo M Santos, Anton Sirota
    Fast fluctuations of oxygen, linked to behavioral and neural dynamics in vivo, cause phasic transients is amperometry-measured cholinergic signals via the mechanism of non-steady-state enzyme kinetics in the choline-oxidase-based biosensor.
    1. Developmental Biology

    Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice

    Georges Raad, Fabrizio Serra ... Valerie Grandjean
    Predisposition to obesity-associated diseases is dependent on the ancestors' diet.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in C. elegans

    Teresa Wei-sy Lee, Heidi Shira David ... David John Katz
    The transgenerational inheritance of lifespan is facilitated by the accumulation of repressive chromatin across generations.
    1. Cell Biology
    2. Physics of Living Systems

    Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends

    Andrea Serra-Marques, Maud Martin ... Anna Akhmanova
    The function and distribution of kinesin motors on exocytotic vesicles is dissected and visualized through a combination of gene knockout experiments, high-resolution microscopy and advanced data analysis.
    1. Immunology and Inflammation

    Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells

    Joseph Wayne M Fowler, Rong Zhang ... William C Sessa
    Detailed biochemical and metabolic analysis of the inflammatory response in human endothelial cells reveals that inflammation directly regulates cholesterol homeostasis.
    1. Chromosomes and Gene Expression

    Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells

    Cristina Cruz, Monica Della Rosa ... Jonathan Houseley
    A widely studied chromatin modification associated with gene promoters is important for proper gene expression across organismal lifetime.
    1. Developmental Biology
    2. Immunology and Inflammation

    Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice

    Ying Wang, Thomas S Chaffee ... Kathryn L Schwertfeger
    A distinct resident macrophage subpopulation that localizes to the adipose stroma and fibrous capsule of the nulliparous mammary gland and to extracellular matrix-enriched stroma surrounding mammary tumors is identified.

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