RNA sequencing and conditional Nova mutants reveal that Nova protein function is necessary for activity-dependent alternative splicing of synaptic genes within somatostatin cortical interneurons and regulates its afferent and efferent connectivity.

Volume electron-microscopic reconstructions of auditory brainstem neurons and their afferent synapses were used to develop a pipeline creating biophysically defined computational models with heterogenous inputs, revealing roles for subthreshold synapses to enhance temporal processing unique features of their dendrites.

Patch-clamp electrophysiology, fluorescence imaging, and computational modeling were used to identify cellular mechanisms underlying maturation of dendritic computations in interneurons.

A theoretical model combines self-supervised predictive learning with structural inductive biases to reveal how quasi-continuous attractors that perform accurate angular path integration can be learned from experience during development in the Drosophila and potentially other animal models.

Building on previous work (Huang et al., 2013), it is shown that single granule cells receive excitatory synaptic input driven by up to three separate sensory modalities in vivo, which demonstrate that individual neurons can contribute to multisensory integration at the input layer of the cerebellar cortex.

Extracellular levels of the neurotransmitter glutamate are maintained at physiologically significant levels at some synapses even in the absence of action potentials.

Setpoints that determine the integrative properties of neurons in the medial entorhinal cortex are established at a population level and differ between animals.

In the zebrafish spinal cord, mixed synapses contribute to neuronal connectivity and resting excitability, which helps explain violations of the well-known 'size principle' of recruitment.

A novel region in the CaV2.1 α1 subunit regulates coupling of synaptic vesicles to CaV2.1 calcium channels, synaptic vesicle release and docking, and the size of the fast and total releasable pools of synaptic vesicles.

Excitatory synapses that occur further away from the postsynaptic cell soma exhibit greater neurotransmitter release probability, which appears to improve signal transfer fidelity for high-frequency afferent firing.