4,677 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Nascent-Seq reveals novel features of mouse circadian transcriptional regulation

    Jerome S Menet, Joseph Rodriguez ... Michael Rosbash
    Genome-wide measurements on mouse liver cells show that transcription, and a particular key transcription factor, have a smaller than expected influence on the mouse circadian system.
    1. Cell Biology

    Tom70-based transcriptional regulation of mitochondrial biogenesis and aging

    Qingqing Liu, Catherine E Chang ... Chuankai Zhou
    Tom70 connects the mitochondrial import to the nuclear transcriptional activity of mitochondrial proteins and controls mitochondrial biogenesis defects during aging.
    1. Genetics and Genomics

    Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy

    Sujatha Jagannathan, Yuko Ogata ... Robert K Bradley
    The myopathic transcription factor DUX4 induces discordant dysregulation of transcript and protein levels, demonstrating a key role for post-transcriptional gene regulation in facioscapulohumeral muscular dystrophy.
    1. Plant Biology

    Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

    Katherine Noelani Chang, Shan Zhong ... Joseph R Ecker
    The plant hormone ethylene regulates the expression of multiple genes in the model plant Arabidopsis, including those that respond to other hormones.
    1. Microbiology and Infectious Disease

    Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members

    Elena Gonzalo-Gil, Patrick B Rapuano ... Richard E Sutton
    A subset of EC/VCs have CD4+T cells with resistance specific to R5-tropic HIV infection associated with transcriptional down-regulation of ccr5, a phenotype that appears to be heritable, across multiple generations.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Transcriptional regulation of neural stem cell expansion in the adult hippocampus

    Nannan Guo, Kelsey D McDermott ... Amar Sahay
    Kruppel-like factor 9 (Klf9) is a transcriptional regulator of neural stem cell expansion in the adult hippocampus.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Transcriptional heterogeneity and cell cycle regulation as central determinants of Primitive Endoderm priming

    Marta Perera, Silas Boye Nissen ... Joshua M Brickman
    The simultaneous expansion of G1 and acceleration of the cell cycle, while ensuring synchronous inheritance of these properties, progressively induces cell identity in differentiation.
    1. Immunology and Inflammation

    Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

    Daisy X Ji, Kristen C Witt ... Russell E Vance
    Repression of type I interferons by SP140 is essential for resistance to Legionella pneumophila and Mycobacterium tuberculosis.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3

    Ho-Ryun Chung, Chao Xu ... Sarah Kinkley
    PHF13 interacts with transcriptional complexes containing RNA polymerase II to recruit/stabilize them at H3K4me2/3 containing active or bivalent promoters.
    1. Cell Biology

    KChIP2 is a core transcriptional regulator of cardiac excitability

    Drew M Nassal, Xiaoping Wan ... Isabelle DeschĂȘnes
    The ion channel accessory subunit KChIP2 has a transcriptional role that provides regulation over miRNA targets, driving the adverse remodeling of key ion channels during cardiac stress and leading to the development of arrhythmia.

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