85 results found
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Isolation and transcriptomic analysis of Anopheles gambiae oenocytes enables the delineation of hydrocarbon biosynthesis

    Linda Grigoraki, Xavier Grau-Bové ... Hilary Ranson
    Delineation of the cuticular hydrocarbon biosynthetic pathway in malaria vectors is a key step in understanding how mosquitoes adapt to anthropogenic change and vector control interventions.
    1. Epidemiology and Global Health

    The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa

    Michelle M Riehle, Tullu Bukhari ... Kenneth D Vernick
    A common chromosome inversion in African malaria mosquito (Anopheles gambiae) is associated with differences in malaria infection, adult resting behavior and ecology, and may aid the most efficient vectors to evade malaria control.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High-resolution species assignment of Anopheles mosquitoes using k-mer distances on targeted sequences

    Marilou Boddé, Alex Makunin ... Mara KN Lawniczak
    Large-scale monitoring of Anopheles populations benefits from a robust and accurate species identification and plasmodium detection method that is applicable to the entire genus.
    1. Microbiology and Infectious Disease

    Hemocyte differentiation to the megacyte lineage enhances mosquito immunity against Plasmodium

    Ana Beatriz F Barletta, Banhisikha Saha ... Carolina Barillas-Mury
    Toll signaling modulates hemocyte differentiation into the megacyte lineage and their recruitment to the midgut greatly enhances mosquito immunity against Plasmodium.
    1. Genetics and Genomics

    Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement

    Astrid Hoermann, Sofia Tapanelli ... Nikolai Windbichler
    Minimal genetic modifications of endogenous mosquito genes allow the tissue-specific expression of anti-malarial effectors and convert them into efficient non-autonomous gene drives.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A transcriptomic atlas of Aedes aegypti reveals detailed functional organization of major body parts and gut regional specializations in sugar-fed and blood-fed adult females

    Bretta Hixson, Xiao-Li Bing ... Nicolas Buchon
    RNAseq profiles of female Aedes body parts, gut regions, and blood-fed guts provide insight into the anatomical patterning of immune and digestive function, and demonstrate the sequential induction of multiple peptidase cohorts over the course of blood meal digestion.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Single-cell analysis of mosquito hemocytes identifies signatures of immune cell subtypes and cell differentiation

    Hyeogsun Kwon, Mubasher Mohammed ... Ryan C Smith
    Single-cell RNA-seq analysis reveals an increased complexity of mosquito hemocytes, enabling the functional and molecular characterization of immune cell sub-populations in Anopheles gambiae.
    1. Epidemiology and Global Health

    Anopheles salivary antigens as serological biomarkers of vector exposure and malaria transmission: A systematic review with multilevel modelling

    Ellen A Kearney, Paul A Agius ... Freya JI Fowkes
    A systematic review with multilevel modelling quantified the positive association between human antibodies to Anopheles salivary proteins with Anopheles-human biting rate and epidemiological measures of malaria transmission, highlighting their potential as a tool to measure vector exposure and malaria transmission.
    1. Epidemiology and Global Health

    Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission

    Wamdaogo M Guelbéogo, Bronner Pamplona Gonçalves ... Chris Drakeley
    Heterogeneity in exposure to malaria vectors, including sporozoite-infected mosquitoes, contributes to the variation in human infection risk and amplifies the local transmission potential.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predicting geographic location from genetic variation with deep neural networks

    CJ Battey, Peter L Ralph, Andrew D Kern
    Neural networks allow fast and accurate prediction of individual spatial locations from genotypes or sequencing data.

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