The chitin-triggered immune response is mediated by a LYK5 and CERK1 receptor complex in Arabidopsis.

CERS1 reduction in aging skeletal muscle contributes to impaired muscle function, myogenesis and increases inflammation and fibrosis, highlighting the significance of very long chain ceramides in age-related muscle homeostasis.

RAB23 regulates calvarial bone and suture development both independently through, and by cross-talk between, Hedgehog and fibroblast growth factor signaling.

Phosphoproteomics identifies β-arrestin 2 phosphorylation at Thr383 by MEK as a key step of GPCR-induced Erk½ activation, thus providing new insight into the molecular mechanism underlying β-arrestin-dependent GPCR-operated signaling.

S-type anion channel activity, which promotes stomatal closure and improves anti-fungal immunity in plants, is directly regulated through phosphorylation by a kinase of the chitin receptor complex.

A zebrafish genetic model of Ewing sarcoma, a pediatric bone cancer, showed how molecules in the normal tissue can support tumor cells, and identified a therapeutic compound that slows tumor growth.

Oocyte maturation and ovulation in the sister group of vertebrates, Ciona intestinalis Type A, are triggered by Ci-VP, the Ciona homolog of a typical neruopeptide, vasopressin.

A plant peptide hormone controls organ shedding by acting as molecular glue that promotes the interaction between two membrane receptor kinases.

New ATP-competitive inhibitors show properties of conformation selection when complexed with the MAP kinase, ERK2, altering movements around the activation loop.