816 results found
    1. Developmental Biology

    Dkk2 promotes neural crest specification by activating Wnt/β-catenin signaling in a GSK3β independent manner

    Arun Devotta et al.
    Dkk2, a member of the Dikkopf family of Wnt antagonists, acts as a positive regulator of Wnt signaling during neural crest formation.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53

    Syafiq Abd Wahab, Dirk Remus
    The mechanism of Dbf4-dependent kinase (DDK) recruitment to replication origins and its regulation by the checkpoint have been identified.
    1. Cell Biology
    2. Neuroscience

    Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104

    Jiaxing Li et al.
    Synaptic defects previously attributed to loss of kinesin function are found to be mediated by the Wnd/DLK axonal injury signaling pathway, which restrains the total levels of presynaptic proteins in response to their accumulation.
    1. Neuroscience

    An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK

    Yan Hao et al.
    Axonal damage sensing kinase DLK is a direct target and mediator of the cAMP effector kinase PKA in a unified mechanism for stimulating axonal regeneration.
    1. Chromosomes and Gene Expression

    Dynamic relocalization of replication origins by Fkh1 requires execution of DDK function and Cdc45 loading at origins

    Haiyang Zhang et al.
    Establishment of replication-timing involves Fkh1-dependent recruitment and execution of DDK function in G1 phase resulting in dynamic relocalization of origins within the nucleus in anticipation of CDK-dependent origin activation.
    1. Neuroscience

    Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength

    Yunbo Li et al.
    The activity levels of two closely related MAPKKK are differentially regulated in Purkinje neuron survival.
    1. Neuroscience

    Inhibiting poly(ADP-ribosylation) improves axon regeneration

    Alexandra B Byrne et al.
    In C. elegans and mouse neurons, the balance between poly(ADP-ribose) glycohydrolases and poly(ADP-ribose) polymerases regulates axon regeneration downstream of DLK-1/MAPKKK signaling.
    1. Cell Biology
    2. Neuroscience

    Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

    Martin Larhammar et al.
    Two seemingly distinct cellular stress response pathways that contribute to neurodegeneration after axonal insults are now revealed to be under the control of a single master regulator of the neuronal injury response, the kinase DLK.
    1. Structural Biology and Molecular Biophysics

    Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

    Yusuke Sugasawa et al.
    Differential, state-dependent occupancy of three discrete binding sites on α1β3 GABAA receptors determines whether a specific neurosteroid analogue potentiates or inhibits GABA-elicited currents or competitively antagonizes neurosteroid action.
    1. Chromosomes and Gene Expression

    EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma

    Ananya Pal et al.
    Inhibition of the lysine methyltransferase G9a blocks oncogenic phenotypes in embryonal rhabdomyosarcoma.

Refine your results by:

Type
Research categories