In vivo imaging of extracellular signal-regulated kinase activity reveals radial ERK activation patterns that are associated with cell cycle progression in the mouse epidermis.
Genetics, in vivo imaging, and unbiased chemical biology screens reveal that Trpv6 functions as a cellular quiescence regulator and delineates a Trpv6-mediated Ca2+ signaling pathway maintaining the quiescent state.
Lineage transformation in lung cancer is dictated by ERK activity and requires permissive chromatin alterations in the context of targeted therapy resistance.
Stephen R Daley, Kristen M Coakley ... Jeroen P Roose
A single point mutation in a Ras activator leads to aberrant constitutive mTOR signaling in peripheral T cells that consequently accumulate as abnormal T helper cells and stimulate the production of autoantibodies by B cells.
Néstor Saiz, Laura Mora-Bitria ... Anna-Katerina Hadjantonakis
A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
Mathematical and experimental analyses suggest that despite their complex architectures, multiple metazoan signaling pathways act in physiological contexts as linear signal transmitters.
Elisabeth Cassier, Nathalie Gallay ... Franck Vandermoere
Phosphoproteomics identifies β-arrestin 2 phosphorylation at Thr383 by MEK as a key step of GPCR-induced Erk½ activation, thus providing new insight into the molecular mechanism underlying β-arrestin-dependent GPCR-operated signaling.
The cancer drug vemurafenib has potent off-target effects on JNK signaling that contribute to the development of squamous cell carcinomas in humans and in mice.
