365 results found
    1. Medicine

    Equity, Diversity and Inclusion: Introducing the MAVEN Leadership Training Initiative to diversify the scientific workforce

    Y Claire Wang, Elizabeth Brondolo ... The MAVEN Leadership Team
    The MAVEN Initiative has been designed to encourage mid-career women scientists, particularly women of color, to move into leadership positions in science.
    1. Medicine

    Biomedical supervisors’ role modeling of open science practices

    Tamarinde L Haven, Susan Abunijela, Nicole Hildebrand
    Supervisors' engagement in open science practices such as data sharing is associated with a greater odds that Ph.D. students engage in these practices and share their data.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene flow mediates the role of sex chromosome meiotic drive during complex speciation

    Colin D Meiklejohn, Emily L Landeen ... Daven C Presgraves
    Selfish genetic elements may either promote or prevent the evolution of reproductive barriers, depending on the extent of gene flow between species.
    1. Neuroscience

    Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals

    Travis D Goode, Reed L Ressler ... Stephen Maren
    The bed nucleus of the stria terminalis (BNST) is required for the expression of defensive behavior to uncertain threats, a function that is central to pathological anxiety.
    1. Neuroscience

    Navigating the garden of forking paths for data exclusions in fear conditioning research

    Tina B Lonsdorf, Maren Klingelhöfer-Jens ... Christian J Merz
    Exclusion of participants in tasks with a learning element can introduce substantial bias and needs to be carefully considered and transparently reported and justified.
    1. Neuroscience

    The neural dynamics of positive and negative expectations of pain

    Christoph Arne Wittkamp, Maren-Isabel Wolf, Michael Rose
    Pain expectation processing shifts from uniform anticipatory activation to valence-specific differentiation during sensory input.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

    Palaniraja Thandapani, Jingwen Song ... Stéphane Richard
    Arginine methylation regulates mRNA translation of key protooncogenes via an RGG/RG motif-containing protein called Aven.
    1. Neuroscience

    Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice

    Christian Thome, Jan Maximilian Janssen ... Maren Engelhardt
    With the new Ankyrin-G-GFP reporter line, researchers can visualize and study neuronal compartments critical for signal transduction without affecting neuronal activity and subcellular integrity of the cells under investigation.
    1. Neuroscience

    Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis

    Benedikt Grünewald, Maren D Lange ... Christian Geis
    Impaired GABAergic and glutamatergic synaptic function and loss of interneurons in the amygdala, hippocampus, and cerebellum cause characteristic disease symptoms in a mouse model juvenile neuronal ceroid lipofuscinosis.
    1. Cancer Biology

    Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

    Timothy M Errington, Alexandria Denis ... Lisa Young
    A project to repeat experiments from high-impact papers in cancer biology did not complete all replications, with challenges ranging from mundane reasons to unexpected methodological issues.

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