15,125 results found
    1. Cell Biology

    Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites

    Adam J Reid, Arthur M Talman ... Mara KN Lawniczak
    Plasmodium parasite transcription shifts dramatically along asexual development, and transmission stages variably express important immune evasion genes, suggesting much interesting biology has until now been hidden by bulk analyses.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae

    Aftab Nadeem, Alexandra Berg ... Sun Nyunt Wai
    MakA, a pore-forming cytotoxin produced by Vibrio cholerae, forms oligomers and remodels membranes into high-curvature tubes, resulting in membrane integrity loss inside acidified organelle lumens or when cultured with cells in an acidic medium.
    1. Structural Biology and Molecular Biophysics

    Hexameric and pentameric complexes of the ExbBD energizer in the Ton system

    Saori Maki-Yonekura, Rei Matsuoka ... Koji Yonekura
    Crystallography and single particle cryo-EM reveal hexameric and pentameric structures of the ExbBD energizer in the Ton system and oligomeric transition, which provides a unique working mechanism and a new vision of dynamic membrane biology.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    Methylation at the C-2 position of hopanoids increases rigidity in native bacterial membranes

    Chia-Hung Wu, Maja Bialecka-Fornal, Dianne K Newman
    Methylation specifically enhances the ability of hopanoids to rigidify membranes under physiologically relevant conditions, which impacts the current interpretation of the 2-methylhopane fossil record.
    1. Neuroscience

    The neural basis for a persistent internal state in Drosophila females

    David Deutsch, Diego Pacheco ... Mala Murthy
    A set of sexually dimorphic neurons in female flies is part of a recurrent neural network and drives minutes-long persistent neural activity and persistent social behaviors.
    1. Cell Biology
    2. Developmental Biology

    Microtubules provide directional information for core PCP function

    Maja Matis, David A Russler-Germain ... Jeffrey D Axelrod
    The Fat/Dachsous/Four-jointed (Ft/Ds/Fj) system provides a spatial signal to organize core PCP proteins via the polarization of microtubules.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary transcriptomics implicates HAND2 in the origins of implantation and regulation of gestation length

    Mirna Marinić, Katelyn Mika ... Vincent J Lynch
    The transcription factor HAND2 evolved uterine expression during the origins of pregnancy and may be important for maternal-fetal immune signaling and parturition.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    In-host population dynamics of Mycobacterium tuberculosis complex during active disease

    Roger Vargas, Luca Freschi ... Maha Reda Farhat
    Bulk whole genome sequencing data can be used to study the genetic variation present in pathogenic bacterial populations over the time-course of a single infection within a host.
    1. Developmental Biology
    2. Evolutionary Biology

    Characterization of the finch embryo supports evolutionary conservation of the naive stage of development in amniotes

    Siu-Shan Mak, Cantas Alev ... Raj K Ladher
    Finch embryos are laid at an earlier stage than other avian embryos and contain cells with similar properties to pluripotent embryonic stem cells from mice.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High-resolution species assignment of Anopheles mosquitoes using k-mer distances on targeted sequences

    Marilou Boddé, Alex Makunin ... Mara KN Lawniczak
    Large-scale monitoring of Anopheles populations benefits from a robust and accurate species identification and plasmodium detection method that is applicable to the entire genus.

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