High-resolution mapping of cohesin-dependent chromatin loops in the genome of budding yeast reveals evolutionarily conserved features for loop formation and cohesin residency as a determinant of loop positioning.

A new genomic method called MChIP-C measures H3K4me3-associated chromatin interactions with extremely high resolution and sensitivity, detecting interactions in over 60% of functionally verified enhancer-promoter pairs.

Using a yeast model of quiescence, it was demonstrated that dramatic changes in local chromatin fiber folding can occur under physiological conditions to regulate cellular processes.

Melanin staining for micro-CT imaging, using a novel application of ionic silver deposition, enables qualitative and quantitative 3D analysis of zebrafish pigmentation and reveals subtle phenotypes missed by light microscopy.

X-ray histotomography produces the first 3-dimensional images with the combined submicron resolution, centimeter fields-of-view, soft-tissue contrast, and potential throughput to enable quantitative, histopathological and centimeter-scale phenotyping for whole-organism phenomics.

Variation in the gene NaMPK4 in plant populations increases reproductive yield, an effect which appears to be independent of soil water availability, neighbor-scale interactions and associations with arbuscular mycorrhizal fungi.

Physical and chemical interactions with bacteria influence the life and death of Emiliania huxleyi, a bloom-forming micro-alga important in global biogeochemical cycles.

Net-winged midge larvae use suction organs covered in spine-like cuticular protrusions to generate powerful attachment on wet and rough surfaces.

A high throughput, full lifespan microscopic analysis reveals that fission yeast does not age but has a finite replicative lifespan.

A regionally resolved single-cell RNA-sequencing analysis of GBM-associated leukocytes reveals distinct activation states of the main immune populations between tumor center, peripheral infiltration zone and blood.