16,972 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

    Leon Y Chan, Christopher F Mugler ... Karsten Weis
    Non-invasive mRNA stability measurements reveal that transcript lifetime is governed by a competition with translation initiation on a transcriptome-wide level.
    1. Genetics and Genomics
    2. Neuroscience

    A genetic, genomic, and computational resource for exploring neural circuit function

    Fred P Davis, Aljoscha Nern ... Gilbert L Henry
    Transcriptomes of cells in the Drosophila visual system combined with anatomy and other information reveal new functional insight into the visual circuit.
    1. Structural Biology and Molecular Biophysics

    Activation-pathway transitions in human voltage-gated proton channels revealed by a non-canonical fluorescent amino acid

    Esteban Suárez-Delgado, Maru Orozco-Contreras ... Leon D Islas
    Combined patch-clamp fluorometry with ANAP, a fluorescent non-canonical amino acid, uncovers transitions in the activation pathway of human HV1 that are modulated by voltage and the pH gradient.
    1. Immunology and Inflammation

    De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness

    Jaemoon Koh, Yeon Duk Woo ... Doo Hyun Chung
    The development and functionalities of invariant natural-killer T cells are dependent upon their cell-intrinsic ACC1-mediated de novo fatty acid synthesis, which greatly affect outcomes of allergic asthma.
    1. Neuroscience

    General features of the retinal connectome determine the computation of motion anticipation

    Jamie Johnston, Leon Lagnado
    Feedforward inhibition generates motion anticipation by selectively decreasing sensitivity to a stimulus as it moves across the latter part of a retinal ganglion cell's receptive field.
    1. Genetics and Genomics

    Nomograms of human hippocampal volume shifted by polygenic scores

    Mohammed Janahi, Leon Aksman ... Andre Altmann
    Accounting for genetic information improved normative models of hippocampal volume in humans by accounting for change equivalent to around 3 years of normal loss for a person aged 65.
    1. Neuroscience

    Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs

    Ming Wu, Aljoscha Nern ... Gerald M Rubin
    Neurons called lobula columnar cells help fruit flies respond appropriately to specific visual cues, such as those signaling an approaching predator.
    1. Chromosomes and Gene Expression

    Inositol polyphosphate multikinase physically binds to the SWI/SNF complex and modulates BRG1 occupancy in mouse embryonic stem cells

    Jiyoon Beon, Sungwook Han ... Daeyoup Lee
    Inositol polyphosphate multikinase physically binds to the core subunits of SWI/SNF complex and plays an important role in regulating BRG1 occupancy and BRG-mediated chromatin accessibility in mouse embryonic stem cells.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice

    Lukas Ded, Jae Yeon Hwang ... Jean-Ju Chung
    Fertilizing mouse spermatozoa, characterized by intact CatSper channels, lack of protein tyrosine phosphorylation, and reacted acrosomes, in the female reproductive tract provide molecular insight into sperm selection for successful fertilization.
    1. Neuroscience

    A searchable image resource of Drosophila GAL4 driver expression patterns with single neuron resolution

    Geoffrey W Meissner, Aljoscha Nern ... FlyLight Project Team
    Single neuron images of Drosophila driver lines reveal neuron shape and are searchable, enabling comparisons to electron microscopy and prediction of intersectional neuron targeting strategies.

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