3,690 results found
    1. Medicine

    RANK+TLR2+ myeloid subpopulation converts autoimmune to joint destruction in rheumatoid arthritis

    Weixin Zhang, Kathleen Noller ... Xu Cao
    The sialylation of RANK+TLR2+ monocytes contributes to osteoclastogenesis and bone destruction in rheumatoid arthritis.
    1. Evolutionary Biology

    Rank orders and signed interactions in evolutionary biology

    Kristina Crona
    Rectangular order perturbations generalize sign epistasis, capture global aspects of fitness landscapes, and clarify how rank order approaches relate.
    1. Structural Biology and Molecular Biophysics

    Real time dynamics of Gating-Related conformational changes in CorA

    Martina Rangl, Nicolaus Schmandt ... Simon Scheuring
    High-speed atomic force microscopy reveals that the open state of the divalent ion channel CorA is highly dynamic and defined by the fast exchange between conformations.
    1. Cell Biology

    The mammalian lectin galectin-8 induces RANKL expression, osteoclastogenesis, and bone mass reduction in mice

    Yaron Vinik, Hadas Shatz-Azoulay ... Yehiel Zick
    The secreted sugar-binding protein galectin-8 causes osteoblasts to secrete factors that promote the differentiation of bone marrow cells into osteoclasts; targeting this protein could therefore potentially help treat diseases associated with excessive bone loss.
    1. Medicine

    Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO

    Naga Suresh Adapala, Gaurav Swarnkar ... Yousef Abu-Amer
    Site-specific modification of NEMO facilitates RANKL signal specificity in myeloid progenitors and serves as a potential target to modulate inflammatory osteolysis through ISG15-dependent autophagy.
    1. Evolutionary Biology
    2. Genetics and Genomics

    High social status males experience accelerated epigenetic aging in wild baboons

    Jordan A Anderson, Rachel A Johnston ... Jenny Tung
    Among the factors that predict fitness in wild baboons, dominance rank in males, but not in females, is the best predictor of epigenetic aging.
    1. Neuroscience

    Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine

    Antoine Cherix, Thomas Larrieu ... Carmen Sandi
    1H-Magnetic resonance spectroscopy at 14T reveals a metabolic signature for anti-depressant-like effects of acetyl-L-carnitine in nucleus accumbens of susceptible mouse.
    1. Computational and Systems Biology

    Inferring genetic interactions from comparative fitness data

    Kristina Crona, Alex Gavryushkin ... Niko Beerenwinkel
    A new mathematical approach can infer higher order genetic interactions from pairwise fitness comparisons between genotypes.
    1. Neuroscience

    Individual history of winning and hierarchy landscape influence stress susceptibility in mice

    Katherine B LeClair, Kenny L Chan ... Scott J Russo
    Socially dominant mice, unlike subordinates, are protected from displaying a common stress-associated behavioral deficit, social avoidance, following exposure to multiple kinds of chronic stress.
    1. Immunology and Inflammation

    Response to comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'

    Christina Hertel, Dmytro Fishman ... Adrian Hayday
    We are writing to reply to the comment by Landegren et al., 2019 about our study (Meyer et al., 2016) on disease-ameliorating autoantibodies.

Refine your results by:

Type
Research categories