7,631 results found
    1. Evolutionary Biology

    Birds land reliably on complex surfaces by adapting their foot-surface interactions upon contact

    William RT Roderick, Diana D Chin ... David Lentink
    When landing, Pacific parrotlets exhibit stereotyped leg and wing dynamics regardless of perch diameter and texture, but foot and claw kinematics become surface-specific upon touchdown to successfully grasp the perch.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

    Zhou Yu, Lauren E Surface ... Erin K O'Shea
    Identification of a transporter complex comprised of SLC37A3 and ATRAID is required for nitrogen-containing bisphosphonates to enter the cytosol from lysosomes and exert their therapeutic effects on bone.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A novel GTP-binding protein–adaptor protein complex responsible for export of Vangl2 from the trans Golgi network

    Yusong Guo, Giulia Zanetti, Randy Schekman
    The ability of epithelial cells to distinguish between domains on opposing cell surfaces within a tissue, a property known as planar cell polarity, relies on proteins and protein complexes directing the traffic of signaling proteins to specific locations on the cell surface membrane.
    1. Structural Biology and Molecular Biophysics

    Three-dimensional flagella structures from animals’ closest unicellular relatives, the Choanoflagellates

    Justine M Pinskey, Adhya Lagisetty ... Daniela Nicastro
    Cryo-electron microscopy reveals previously undescribed structural features of choanoflagellate flagella and provides new insights into flagellar evolution.
    1. Physics of Living Systems

    Learning developmental mode dynamics from single-cell trajectories

    Nicolas Romeo, Alasdair Hastewell ... Jörn Dunkel
    A computational framework enables the inference of hydrodynamic continuum models for collective cell migration from live-cell imaging data recorded in zebrafish embryos.
    1. Immunology and Inflammation

    Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity

    Brogan Yarzabek, Anita J Zaitouna ... Malini Raghavan
    Lymphocytes and monocytes maintain their cell surface HLA-B via different mechanisms, which in turn differently influence cell-surface expression, half-life and peptide receptivity of HLA-B allotypes.
    1. Structural Biology and Molecular Biophysics

    How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

    Xuefeng Ren, Sang Yoon Park ... James H Hurley
    The structure of the Nef:AP-2 complex has been determined and used as the basis of a model that explains how HIV-1 Nef downregulates the CD4 receptor from the surface of the infected cells.
    1. Structural Biology and Molecular Biophysics

    Contacts-based prediction of binding affinity in protein–protein complexes

    Anna Vangone, Alexandre MJJ Bonvin
    The number of contacts at the interface of a protein–protein complex, together with the properties of the surface, provides a simple, but well-performing predictor of binding affinity.
    1. Physics of Living Systems

    Flower-like patterns in multi-species bacterial colonies

    Liyang Xiong, Yuansheng Cao ... Lev Tsimring
    Mechanical interactions between bacterial species with different motility characteristics play an important role in spatial-temporal dynamics of multi-species bacterial colonies and can lead to formation of complex patterns.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein

    Ilona Rissanen, Robert Stass ... Thomas A Bowden
    An integrated cryoEM and X-ray crystallography study resolves the structural basis for antibody-mediated targeting of the hantavirus fusion glycoprotein and provides insight into the conformational landscape of the hantavirion surface.

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