Adam M Corrigan, Edward Tunnacliffe ... Jonathan R Chubb
Rather than switching between discrete on and off states, gene transcription exists in a spectrum or continuum of states, with a slowly changing initiation rate modulating the levels of activity.
A computational framework enables the inference of hydrodynamic continuum models for collective cell migration from live-cell imaging data recorded in zebrafish embryos.
Using a combination of all-atom molecular simulation and continuum membrane mechanics, M2 channels from influenza are shown to be stabilized in negative Gaussian curvature regions, such as the neck of budding viral particles, only in C2-symmetric conformations.
Autonomous patterns of cell contraction in the context of localized apical extracellular matrix constraints specify tissue stresses that reshape the wing epithelium.
Jennifer P Owen, Robert N Kelsh, Christian A Yates
A mathematical modelling approach to understanding zebrafish stripe pattern formation exemplifies a biological rule-set sufficient to generate wild-type and a diverse range of mutant patterns.
The animacy organization in human ventral visual cortex is driven by both the presence of animal-diagnostic visual features and the psychological property of agency.
Sven Dorkenwald, Nicholas L Turner ... H Sebastian Seung
Sizes of synapses between layer 2/3 pyramidal cells in mouse primary visual cortex are well modeled by the sum of a binary variable and an analog variable drawn from a log-normal distribution.
Crosses of loaches with various genetic and karyptype divergence cause different reproductive outcomes in hybrids, ranging from sexual reproduction to sterility, inviability, and clonality among females.