853 results found
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    A continuum model of transcriptional bursting

    Adam M Corrigan, Edward Tunnacliffe ... Jonathan R Chubb
    Rather than switching between discrete on and off states, gene transcription exists in a spectrum or continuum of states, with a slowly changing initiation rate modulating the levels of activity.
    1. Physics of Living Systems

    Learning developmental mode dynamics from single-cell trajectories

    Nicolas Romeo, Alasdair Hastewell ... Jörn Dunkel
    A computational framework enables the inference of hydrodynamic continuum models for collective cell migration from live-cell imaging data recorded in zebrafish embryos.
    1. Structural Biology and Molecular Biophysics

    Membrane curvature sensing and symmetry breaking of the M2 proton channel from Influenza A

    James Lincoff, Cole VM Helsell ... Michael Grabe
    Using a combination of all-atom molecular simulation and continuum membrane mechanics, M2 channels from influenza are shown to be stabilized in negative Gaussian curvature regions, such as the neck of budding viral particles, only in C2-symmetric conformations.
    1. Neuroscience

    Drosophila uses a tripod gait across all walking speeds, and the geometry of the tripod is important for speed control

    Chanwoo Chun, Tirthabir Biswas, Vikas Bhandawat
    Drosophila uses a gait close to the tripod throughout its speed range, and changes in speed are accompanied by changes in the geometry of the tripod.
    1. Cell Biology
    2. Physics of Living Systems

    Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophila pupal wing

    Raphaël Etournay, Marko Popović ... Suzanne Eaton
    Autonomous patterns of cell contraction in the context of localized apical extracellular matrix constraints specify tissue stresses that reshape the wing epithelium.
    1. Computational and Systems Biology
    2. Developmental Biology

    A quantitative modelling approach to zebrafish pigment pattern formation

    Jennifer P Owen, Robert N Kelsh, Christian A Yates
    A mathematical modelling approach to understanding zebrafish stripe pattern formation exemplifies a biological rule-set sufficient to generate wild-type and a diverse range of mutant patterns.
    1. Neuroscience

    The nature of the animacy organization in human ventral temporal cortex

    Sushrut Thorat, Daria Proklova, Marius V Peelen
    The animacy organization in human ventral visual cortex is driven by both the presence of animal-diagnostic visual features and the psychological property of agency.
    1. Developmental Biology
    2. Physics of Living Systems

    Self-organized patterning of cell morphology via mechanosensitive feedback

    Natalie A Dye, Marko Popović ... Frank Jülicher
    Radial patterns of cell morphology in the Drosophila larval wing emerge through mechanosensitive dynamics of cell polarity.
    1. Neuroscience

    Binary and analog variation of synapses between cortical pyramidal neurons

    Sven Dorkenwald, Nicholas L Turner ... H Sebastian Seung
    Sizes of synapses between layer 2/3 pyramidal cells in mouse primary visual cortex are well modeled by the sum of a binary variable and an analog variable drawn from a log-normal distribution.
    1. Evolutionary Biology

    Genetic and karyotype divergence between parents affect clonality and sterility in hybrids

    Anatolie Marta, Tomáš Tichopád ... Karel Janko
    Crosses of loaches with various genetic and karyptype divergence cause different reproductive outcomes in hybrids, ranging from sexual reproduction to sterility, inviability, and clonality among females.

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