496 results found
    1. Microbiology and Infectious Disease

    A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation

    Rongsui Gao et al.
    Functional definition of NrtR and the discovery of its acetylation represents a first paradigm for linking protein acetylation to bacterial central NAD+ metabolism.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Protein kinase C coordinates histone H3 phosphorylation and acetylation

    Zoulfia Darieva et al.
    Chromatin structure is altered following DNA replication stress through the activity of protein kinase C signalling which leads to functionally coupled histone H3 phosphorylation and acetylation events.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters

    Nikolai Petkau et al.
    Acetylation of the circadian transcription factor BMAL1 by the acetyltransferase TIP60 is crucial for recruitment of the pause release factors to clock gene promoters and productive elongation of these genes.
    1. Biochemistry and Chemical Biology

    RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not

    Michael W Webster et al.
    Biochemical reconstitution of deadenylation and analysis of binding kinetics reveals how RNA-binding proteins select their mRNA targets.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors

    Silvia Peluso et al.
    FGF signalling is responsible for priming the developmental enhancer ZRS across the distal limb mesenchyme during development, allowing ETS factors to modulate its activity through balancing histone acetylation.
    1. Chromosomes and Gene Expression

    Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription

    Vincenzo Di Cerbo et al.
    The acetylation of histones at specific sites close to DNA can regulate transcription.
    1. Cell Biology

    SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation

    Mohsen Sarikhani et al.
    Mass spectroscopy, molecular modeling and/or molecular dynamics simulations reveal how acetylation regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation.
    1. Microbiology and Infectious Disease

    Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites

    Fabien Sindikubwabo et al.
    A versatile acetylation-methylation switch at lysine 31 on the lateral surface of histone H4 contributes to chromatin structure in apicomplexan parasites.
    1. Structural Biology and Molecular Biophysics

    Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123

    Sojin An et al.
    Structural and biochemical studies of Kap123 revealed the mechanisms by which Kap123 recognizes H3- and H4-NLSs through two lysine-binding pockets and by which evolutionarily conserved diacetylation of H4-NLS facilitates Kap123-H3-NLS mediated nuclear translocation.
    1. Human Biology and Medicine

    Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

    Kotaro Shirakawa et al.
    Salicylic acid, the precursor to aspirin, is an anti-tumor agent that blocks protein acetylation.

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