Functional subsets of helper CD4+ T cells carry TCR repertoires with distinct features that are reproducible across donors and are partially acquired at the level of thymic selection.

Strategies to enhance Tfh cells for HIV-vaccine antibody persistence and protection is pivotal for vaccine success.

A novel binning approach provides evidence for super-functional T cells with high activation potential and which exhibit Tfh-like functionalities and can help B cells.

6-Phosphogluconate dehydrogenase controls regulatory T cells metabolism with shifts to Th1, Th2, and Th17 phenotypes.

Differentiation of CD4 T cells into CD4 T follicular helper cells during viral infection in mice is promoted by tumor growth factor beta.

By comparing different subsets in mouse inducible Tfh (iTfh) cells and human circulating Tfh (cTfh) cells after vaccination, Tfh17 cells were found to be better than Tfh1 or Tfh2 cells in maintenance and support immunological memory of humoral immunity.

SARS-CoV-2 experienced ocrelizumab-treated MS patients benefit from SARS-CoV-2 mRNA vaccination by inducing broadprotective CD8+ T-cells, whereas methotrexate-treated RA patients induce delayed but strong antibody responses, which support vaccine strategies for these patient groups.

PDK1 serves as a critical role for intrinsically promoting T follicular helper cell differentiation and effector functions via controlling expression level of TCF1.

Genetic analyses reveal biological insight of a novel risk locus into systemic lupus erythematosus susceptibility.

CD4+ T cells responding to chronic lymphocytic choriomeningitis virus infection display transcriptional heterogeneity that is marked by both lineage-specific gene expression profiles and core gene expression programs that are upregulated and conserved across multiple distinct populations of T helper cells.