183 results found
    1. Ecology

    Algal-fungal symbiosis leads to photosynthetic mycelium

    Zhi-Yan Du, Krzysztof Zienkiewicz ... Gregory M Bonito
    The capacity for symbiosis between photosynthetic microalgae and early diverging lineages fungi was demonstrated with microscopy and stable isotope exchange of carbon and nitrogen.
    1. Cancer Biology
    2. Cell Biology

    Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells

    Yoichiro Harada, Yu Mizote ... Naoyuki Taniguchi
    Proteomic and metabolomic analyses reveal how mannose exerts its anticancer activity.
    1. Ecology

    Symbiosis: Algae and fungi move from the past to the future

    Paola Bonfante
    The ability of photosynthetic algae to enter the hyphae of a soil fungus could tell us more about the evolution of these species.
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology

    Gene and protein expression and metabolic flux analysis reveals metabolic scaling in liver ex vivo and in vivo

    Ngozi D Akingbesote, Brooks P Leitner ... Rachel J Perry
    Transcriptomic, enzyme activity, and flux data demonstrate that metabolic scaling, the inverse correlation between body size and metabolic rate per gram of tissue, is a conserved phenomenon that occurs at multiple physiological levels and in multiple tissues.
    1. Medicine
    2. Immunology and Inflammation

    A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies

    Thomas Balligand, Claire Carpenet ... Maarten Dewilde
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cell Biology
    2. Cancer Biology

    Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

    Hongyun Zhao, Lifeng Yang ... Deepak Nagrath
    Exosomes from cancer-associated fibroblasts enhance the "Warburg effect" in tumors and contain de novo metabolites that can contribute to the entire compendia of central carbon metabolism within cancer cells.
    1. Cell Biology

    Nicotinamide adenine dinucleotide is transported into mammalian mitochondria

    Antonio Davila, Ling Liu ... Joseph A Baur
    Stable isotope labeling reveals that NAD crosses the inner membrane of mammalian mitochondria via an unknown transporter.
    1. Microbiology and Infectious Disease

    Heavy isotope labeling and mass spectrometry reveal unexpected remodeling of bacterial cell wall expansion in response to drugs

    Heiner Atze, Yucheng Liang ... Michel Arthur
    Labeling with 13C and 15N in the absence of metabolic engineering enabled the exploration of peptidoglycan metabolism at a very fine level of detail based on kinetic characterization of isotopologues predicted to occur according to known recycling and biosynthesis pathways.
    1. Cancer Biology

    Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

    Allison N Lau, Zhaoqi Li ... Matthew G Vander Heiden
    Isotope tracing into macromolecules enables functional analysis of metabolism in specific cell populations in tumors and provides insight into metabolic differences between cancer and stromal cells in their endogenous microenvironment.
    1. Ecology

    Oxygen isotopes suggest elevated thermometabolism within multiple Permo-Triassic therapsid clades

    Kévin Rey, Romain Amiot ... Christophe Lécuyer
    Two therapsid clades, dicynodonts and cynodonts, independently acquired and developed an endotherm-like thermoregulation during the Late Permian period, that probably helped them to survive the major global climate and environmental fluctuations of the end-Permian.

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