5,410 results found
    1. Cell Biology
    2. Developmental Biology

    PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix

    S Nahuel Villegas et al.
    A signalling cascade involving PI3K/Akt1 remodels the extra-cellular matrix to achieve atypical cellular responses and control cell fate specification within the embryonic endoderm.
    1. Cancer Biology
    2. Genetics and Genomics

    MITF reprograms the extracellular matrix and focal adhesion in melanoma

    Ramile Dilshat et al.
    Analysis of knockout and knockdown melanoma cells and TCGA melanoma data shows that the microphthalmia-associated transcription factor (MITF) is a major repressor of extracellular matrix (ECM) and focal adhesion genes.
    1. Evolutionary Biology

    A Bayesian approach to dynamic homology of morphological characters and the ancestral phenotype of jawed vertebrates

    Benedict King, Martin Rücklin
    The ancestor of all known jawed vertebrates possessed a maxilla and premaxilla and was similar in morphology to the 'maxillate placoderms' from China.
    1. Neuroscience

    A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade

    Maria D Purice et al.
    An unbiased transcriptional profiling screen reveals the secreted matrix metalloproteinase MMP-1 is a transcriptional target of the ensheathing glial receptor Draper following acute axon injury in adult Drosophila.
    1. Cancer Biology

    Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

    Ritu Chaudhary et al.
    Functional and mechanistic analysis of p53-regulated lncRNA PINCR and its interacting RNA-binding protein Matrin 3 uncovers context-dependent regulation of specific p53 target genes during DNA damage.
    1. Cell Biology

    The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes

    Maria Benito-Jardón et al.
    The fibronectin synergy site is only required in vivo when forces exceed or αvβ3 integrin levels fall below certain thresholds.
    1. Physics of Living Systems

    Extracellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility

    Monika E Dolega et al.
    Theoretical predictions and experiments on multicellular aggregates indicate that the extracellular matrix acts as a mechanical sensor, which regulates cell proliferation and migration in a three-dimensional environment.
    1. Structural Biology and Molecular Biophysics

    Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

    Gregory M Martin et al.
    Diverse KATP channel inhibitors occupy a common binding pocket and stabilize an interaction between Kir6.2 and SUR1 to allosterically control gating and promote the assembly and trafficking of nascent channels.
    1. Stem Cells and Regenerative Medicine

    Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss

    Judy Lisette Martin et al.
    A new platform for imaging live Drosophila adults yields vivid movies of the midgut over prolonged time scales, opening the door to the real-time study of organ renewal dynamics in a near-native context.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Anti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM

    Gregory M Martin et al.
    A structure of a pancreatic ATP-sensitive potassium channel complex at 3.63Å resolution obtained by cryo-electron microscopy reveals how a commonly used anti-diabetic drug interacts with and inhibits the channel to stimulate insulin secretion.

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