12,295 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

    Liselot Dewachter, Julien Dénéréaz ... Jan-Willem Veening
    High-throughput single-cell based, genome-wide gene silencing screening (sCRilecs-seq) revealed that drugging the mevalonate pathway resensitizes amoxicillin-resistant pneumococci.
    1. Evolutionary Biology

    A β-carotene-binding protein carrying a red pigment regulates body-color transition between green and black in locusts

    Meiling Yang, Yanli Wang ... Le Kang
    Body color change of locusts reveals a new 'palette effect' mechanism by which the red βCBP–β-carotene pigment complex acts as a switch to coordinate between black and green coloration.
    1. Computational and Systems Biology
    2. Neuroscience

    Automatically tracking feeding behavior in populations of foraging C. elegans

    Elsa Bonnard, Jun Liu ... Monika Scholz
    A new tool enables measuring feeding and locomotion simultaneously which will enable insights into environmental, developmental, neuronal, and genetic factors underlying behavioral regulation.
    1. Cell Biology
    2. Neuroscience

    Endosomal sorting protein SNX4 limits synaptic vesicle docking and release

    Josse Poppinga, Nolan J Barrett ... Jan RT van Weering
    SNX4 influences synaptic vesicle recruitment at the active zone, linking endosomal sorting to docked vesicle density and modulating neurotransmission efficiency during sustained activity.
    1. Biochemistry and Chemical Biology

    Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP protein ENAH

    Theresa Hwang, Sara S Parker ... Amy E Keating
    Short linear motifs throughout the intrinsically disordered proteome use sequence context in diverse ways to target actin remodeler ENAH.
    1. Neuroscience

    Rapid categorization of natural face images in the infant right hemisphere

    Adélaïde de Heering, Bruno Rossion
    Diverse photographs of human faces against their natural background trigger a specific electrical response in the right hemisphere of the brain in infants aged 4–6 months.
    1. Biochemistry and Chemical Biology

    A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

    Theresa Hwang, Sara S Parker ... Amy E Keating
    A peptide from PCARE achieves >100-fold binding specificity for the EVH1 domain of ENAH, a protein important for metastasis, using a conformational shift mechanism unavailable to ENAH's closely related paralogs VASP and EVL.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

    Justin M Jenson, Jeremy A Ryan ... Amy E Keating
    Short peptides that bind tightly to anti-apoptotic protein Bfl-1 but not other Bcl-2 family members provide a tool for diagnosing cancer cell survival mechanisms and a lead for developing new therapeutics.
    1. Neuroscience

    Cerebral blood flow and cerebrovascular reactivity are preserved in a mouse model of cerebral microvascular amyloidosis

    Leon P Munting, Marc Derieppe ... Louise van der Weerd
    The causal link between capillary amyloid‑β accumulation in the brain and cerebrovascular dysfunction, previously established in the Tg‑SwDI mouse model, is to be mitigated and remains to be fully uncovered.
    1. Ecology
    2. Microbiology and Infectious Disease

    Recurring patterns in bacterioplankton dynamics during coastal spring algae blooms

    Hanno Teeling, Bernhard M Fuchs ... Rudolf I Amann
    Dynamic successive blooms of clades of planktonic marine bacteria that can be observed during blooms of marine algae follow discernible patterns, part of which might be explained by substrate-induced forcing.

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