Direct reprogramming of smooth muscle cells from HGPS patients revealed that BMP4 is a key contributor of vascular degeneration and might represent a new therapeutic target.

Transiently reprogramming human fibroblasts up to the maturation phase rejuvenates cells according to several aging markers whilst enabling them to return to their original identity.

During reprogramming of human fibroblasts to naïve iPSCs there is transient reactivation of transcripts with the characteristics of 8-cell-stage-embryos.

Variation in efficiency, speed and path during transdifferentiation and reprogramming originates from two pre-B cell subpopulations with reciprocal propensity towards each fate conversion.

Epigenetic reprogramming of the distinct repressive marks H3K27me3 or H3K9me2 guides the transition between the haploid and diploid life forms that encompass the life cycle of land plants.

Partial chemical reprogramming is able to reduce the biological age of cells by diverting them to a different metabolic state marked by a strong upregulation of mitochondrial oxidative phosphorylation.

A mutant impaired for ribosome recycling exhibits translational reprogramming wherein strong mRNAs outcompete weak mRNAs, also observed when preinitiation complexes are diminished by eIF2α phosphorylation or 40S ribosomal subunit depletion.

Induced neuronal cells acquire epigenomic signatures specific to matured neurons.

Chemotherapy remodels lung adenocarcinoma’s tumor microenvironment by driving metabolic reprogramming and shifting immune cell functions to modulate tumor progression and immune responses.

An in vitro chemical screen with single-cell sequencing output leads to the identification of Metformin as an in vivo enhancer of Muller glia to neuron reprogramming in mice.