A single-nucleotide I232T polymorphic change in FcγRIIB's transmembrane domain bends FcγRIIB's ectodomains toward cell membrane to allosterically hinder FcγRIIB's ligand association, providing novel molecular mechanism for functional loss of FcγRIIB-I232T.

Longstanding eco-evolutionary theories are tested using shotgun metagenomic data from the human gut microbiome, showing links between community diversity and the evolutionary trajectory of a focal species within the community.

For many bacterial species, recombination dominates genome evolution and phylogenetic patterns that have so far been assumed to reflect clonal relationships, in fact reflect variation in recombination rates across lineages.

The effect of balancing selection on the human genome is greater than previously appreciated, especially affecting large deletion variations.

Natural selection shaped CHC22 clathrin genetic variation in humans with different diets and potentially influenced the human insulin response.

Fine mapping of transposable element presence/absence variation amongst 216 Arabidopsis strains uncovers widespread novel genetic diversity that underlies differences in transcription and DNA methylation patterns.

There is limited epigenetic conservation of lineage-specific DNA elements in Treg cells, and genetic variation in Treg cell specific enhancers is associated with autoimmune disease.

A mouse model reveals that a p53 SNP impacts longevity via modulating the balance of cancer risk and the self-renewal function of stem/progenitor cells, which supports a role of p53 in regulation of longevity.

An innovative strategy in genome analysis has generated a detailed description of how pathogens mutate when facing human genetic diversity.

Methylated CpG sites are saturated for T mutations in a sample of 390K human exomes, providing a test case for inferences about fitness effects in human genes, and insight into the interpretation of mutations as pathogenic using reference datasets.