Analysis of inositol pyrophosphate dynamics upon inorganic phosphate (Pi) starvation identifies 1,5-IP8 as the inositol pyrophosphate isomer signaling Pi sufficiency to the SPX domain of Pho81 that controls the transcriptional Pi starvation program.
Characterization of an extra-membrane site in IKs formed by KCNQ1 S1, Pore and S6 domains and the near extracellular region of KCNE1, which forms a binding pocket for channel activators.
Xinle Zou, Sri Karthika Shanmugam ... Henry M Colecraft
Targeted recruitment of protein kinase A subunits enables distinctive regulation of the functional expression of a potassium channel depending on whether the enzyme is targeted to a pore-forming or auxiliary subunit.
Structural characterization of human RPA70N association with a series of DNA damage response proteins reveals versatile protein interaction mechanisms that help to recruit DNA repair proteins to the damage site quickly and efficiently.
Valerie Ann Perez, David W Sanders ... Marc I Diamond
Knockout of the J domain protein DnaJC7 reduces tau aggregate clearance and increases intracellular tau seeding for recombinant and human brain-derived tau seed sources.
A biochemical approach using the Wnt pathway as a model system demonstrates a new mechanism for specificity in interconnected signaling networks through scaffold-mediated shielding of bound proteins.
Gautam Susarla, Priyanka Kataria ... Patrick D'Silva
Yeast DJ-1 homologs are molecular erasers of glycation adducts on cellular macromolecules and preserve mitochondrial health through redistributing into mitochondria under elevated carbonyl stress.
Sophia Gessner, Zela Alexandria-Mae Martin ... Digby F Warner
The interaction of ImuB with the β sliding clamp is essential for induced mutagenesis in mycobacteria and could be a novel target for new anti-tuberculosis drugs designed to inhibit the emergence of genetic resistance.
