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Why do some inhibitors select the on-state in ERK2, a kinase that is involved in many signaling pathways in cells, whereas others bind to more than one conformation?

Carefully controlling the level of protein synthesis reduction and mode of translation inhibitor action reveal different and sometimes opposing phenotypic effects following proteostasis stress, wherein protection via initiation inhibition specifically depends on heat shock factor 1.

A subtle mutation in the ATP-binding site of inositol hexakisphosphate kinases increases their conformational flexibility and thereby makes them susceptible to isozyme-selective, allosteric inhibition.

Inducing the formation of mitochondrial respiratory chain supercomplexes in Drosophila melanogaster, where they are normally absent, does not have any noticeable impact in the function of the respiratory chain.

Live human pancreatic α-cells can be purified effectively using zinc-based reaction probe diacetylated Zinpyr1 and cultured as pseudoislets without losing their viability and function.

Deletion of optic atrophy 1 in brown adipose tissue induces secretion of growth differentiation factor 15 as a batokine to attenuate diet-induced obesity and improve glucose clearance, hepatic steatosis, and thermoregulation in mice by increasing energy expenditure.

Circulating high-molecular-weight (cHMW) adiponectin levels increased with age until centenarians, and the contribution of known major factors associated with cHMW adiponectin levels including BMI varied with age, suggesting that its physiological significance also varies with age in the oldest old.

Carbon-fixing organelles, called carboxysomes, link to their spatial organization system in the bacterial cell by a hexameric protein that forms pH-dependent condensates via a nuanced multidomain mechanism.

Engineered mesenchymal stem cells (MSCs) could produce mutant β-galactosidase and trigger nitric oxide (NO) release when the NO prodrug is systemically administered, which can achieve NO release in a precise spatiotemporal manner and augment the therapeutic efficiency of MSCs.

The previously uncharacterized, evolutionarily conserved FAM104 proteins VCF1/2 stimulate the nuclear import of p97/VCP, with their absence causing reduced nuclear p97/VCP levels, slow growth, and hypersensitivity to pharmacological inhibition of p97/VCP.