Browse our latest Biochemistry and Chemical Biology articles

Allosteric mechanism of dual β-lactam binding in L,D-transpeptidase from Mycobacterium tuberculosis.

Although the genetic code uses three DNA base pairs to encode one amino acid, it is surprisingly tolerant to four-base codons, which can be used to incorporate nine of the twenty amino acids without any protein engineering.

Genetic architecture of muscle secreted protein functions are dominated by sex.

Biochemical approaches and cellular experiments show a novel effect of METTL3 on homologous recombination repair and chemotherapeutic response via the m6A-YTHDC1-dependent regulation of the EGF/RAD51 axis.

The bacterial pathogen Listeria monocytogenes requires respiration for the maintenance of cellular redox homeostasis.

Engineering transfer RNAs to read codons consisting of four bases requires changes in tRNA that go beyond the anticodon sequence.

The redox reagent dithiothreitol causes toxicity by depleting S-adenosylmethionine levels, and dietary vitamin B12 could alleviate this toxicity via the methionine synthase enzyme.

Deciphering the mechanism of action of a large family of natural and synthetic cytotoxic lipids bioactivated by enantiospecific oxidation into protein-reactive species inspires the development of enzyme-specific prodrugs.

Single particle cryo-electron microscopy associated with functional studies reveal a critical role of N- and C-terminal tails in the autoinhibition of the disease-related ATP8B1-CDC50A lipid flippase, the possible role of phosphorylation in autoinhibition relief, and strong activation by PI(3,4,5)P₃.

Poly(ADP-ribose) (PAR) Trackers (PAR-Ts) are optimized PAR sensors that allow the detection and quantification of PAR levels in extracts, living cells, and living tissues with high sensitivity, and with temporal and spatial precision, in many different experimental and biological systems.