Browse our latest Biochemistry and Chemical Biology articles

The first recently discovered inhibitors of lysine biosynthesis with in planta activity have a dual-target mode of action, which provides proof-of-concept for the development of multi-target ‘resistance-resistant’ herbicides with a novel mode of action.

PLC-γ isozymes are activated by a combination of receptor engagement and membrane proximity.

Metabolomics data reveals unique metabolic insights into how cavefish adapt to nutrient limited environments while staying healthy.

Using mass spectrometry to study protein composition of translating ribosomes under unstressed or stress conditions, aspartate aminotransferase 2 (Aat2) is identified as a metabolic enzyme with a moonlighting function in the yeast integrated stress-response pathway.

A physics-based, statistically rigorous mathematical model enables automated, objective interpretation of images from single-molecule fluorescence colocalization microscopy experiments.

Effective antiestrogens engage a new structural interaction to improve therapeutic antagonism in hormone-resistant breast cancer cells expressing Y537S estrogen receptor alpha.

METTL18 methylates histidine 245 of ribosomal protein RPL3, retards ribosome traversal at tyrosine codons, and thus ensures nascent protein folding for proteostasis maintenance.

Global proteomic and acetylomic analyses reveal how skeletal muscle adapts to high-intensity interval training including adaptations to processes regulating metabolism and contraction.

The central RNA interference protein, human Argonaute-2, releases its target following phosphorylation on a critical loop in the protein, freeing microRNA-bound Argonaute-2 to seek out and repress additional targets.

Genetically induced conformational modulation of eIF2B activates the Integrated Stress Response by impairing nucleotide exchange.