Browse our latest Biochemistry and Chemical Biology articles

Condensation of cytosolic protein YBX1 into processing bodies reveals mechanisms for efficient and selective sorting of proteins and their cognate microRNAs into exosomes.

The Shu complex enables lesion bypass of specific alkylation-induced DNA damage including abasic sites and 3-methyl-cytosine.

A series of experiments at the molecular level reveal the underlying mechanism of how a gene activates liver glucose production to regulate the blood glucose metabolism in mice.

Cold detecting thermoreceptor TRPM8's signalling is diminished with ageing which leads to an impaired response to cold observed in ageing.

Organ-selective drug action of traditional Chinese medicine that generates systemic immune mediators is proposed and reviewed as a novel mechanistic angle to develop new immunomodulatory drugs.

At most physiological concentrations, the short-chain fatty acids propionate and butyrate affect histone acetylation by modifying and activating the acetyltransferase p300/CBP, rather than by inhibiting histone deacetylases.

Circulating cell-free DNA studies should control for participants' physical activity to avoid its confounding effect on total cell-free DNA level.

UV-Vis- and IR-spectroscopy provides insights into the light-induced enzyme activity of a rhodopsin guanylyl cyclase by tracking the substrate turnover with atomic resolution in real-time and correlating it with the structural changes of the protein.

Molecular, cellular, and computational analyses reveal key insights into PP2A/B55α's mechanisms of substrate recruitment and active site engagement, and facilitate identification/validation of new substrates, a step towards understanding PP2A/B55α's role in multiple cellular processes.

Biochemical analysis reveals the entire route of oligosaccharide processing from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), and the enzymes (EDEM2 and EDEM3/1) responsible for endoplasmic reticulum-associated degradation of misfolded glycoproteins.