Oncoprotein BCL6 confers tumor adaptive resistance to genotoxic stress through the IFN-BCL6-PTEN axis in solid tumors and presents a promising combinational target for chemo-sensitization.
Chromosomal instability of cancer can be quantitatively measured by phylogenetic analysis of 200 tumor cells while using evolutionary principles to account for cellular selection.
Sandhya Balasubramanian, Matteo Andreani ... Michela Di Virgilio
Replication stress induces phosphorylation events within RIF1 intrinsically disordered region that are essential for RIF1's role in DNA replication fork protection.
Yifan Wang, C Richard Boland ... Natalia L Komarova
A mathematical model of colorectal cancer initiation shows that a change in cells’ kinetic parameters due to aspirin can account for an observed reduction in advanced adenoma age- incidence in patients treated with aspirin.
Lisa L Kirkemo, Susanna K Elledge ... James A Wells
Enzyme tethering of promiscuous biotinylators to the cell surface allows for more rapid and efficient comparative surface proteomic analysis of cells and extracellular vesicles.
Mucosal-associated invariant T cells, an emerging member of the innate-like T cells abundant in humans bridging the innate and the adaptive immunity, could be exploited as a novel tool for cancer immunotherapy through cell reprogramming.
Jennifer Patritti Cram, Jianqiang Wu ... Nancy Ratner
In a mouse model of neurofibromatosis type 1, the purinergic receptor P2RY14 is a key regulator of Schwann cell precursor self-renewal and proliferation, of neurofibroma tumor initiation and of mouse survival.
Joshua Hatterschide, Paola Castagnino ... Elizabeth A White
Papillomavirus E7 proteins activate the YAP1 oncogene in basal epithelial cells by degrading PTPN14, in doing so promoting basal cell retention and contributing to carcinogenesis.
