Giulia Di Felice, Giovanni Visci ... Paolo Boffetta
A twofold increased risk of adverse outcomes (mortality, ICU admission, and severity of COVID-19) has been demonstrated in unvaccinated COVID-19 patients with cancer compared to COVID-19 patients without cancer.
Modulation of dermal adipocytes contributes to skin homeostasis and provides a promising new therapeutic strategy in the treatment of EGFRI-related skin disorders.
Elena Vasileva, Mikako Warren ... James F Amatruda
A zebrafish genetic model of Ewing sarcoma, a pediatric bone cancer, showed how molecules in the normal tissue can support tumor cells, and identified a therapeutic compound that slows tumor growth.
Irradiation of normal human fibroblasts and mice in conditions mimicking standard external X-ray radiotherapy protocols highlights that noncancerous cells surrounding the planning target volume accumulate DNA single-strand breaks but almost no double-strand breaks, putting them in a pre-cancerous senescent state.
Alejandro La Greca, Nicolás Bellora ... Patricia Saragüeta
Binding of progesterone receptor and transcription factor PAX2 to pre-assembled permissive chromatin compartments regulates endometrial cancer gene expression under estrogenic conditions.