Browse our latest Cancer Biology articles

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    1. Cancer Biology

    Glutamine deprivation triggers NAGK-dependent hexosamine salvage

    Sydney Campbell, Clementina Mesaros ... Kathryn E Wellen
    Hexosamine salvage through the enzyme N-acetylglucosamine kinase is stimulated in nutrient-limited conditions and supports pancreatic tumor growth.
    1. Cancer Biology
    2. Genetics and Genomics

    BRAFV600E induces reversible mitotic arrest in human melanocytes via microRNA-mediated suppression of AURKB

    Andrew S McNeal, Rachel L Belote ... Robert L Judson-Torres
    Oncogenic BRAF causes genome duplication and reversible growth arrest in human melanocytes that is conditional on microRNA expression and differentiation state.
    1. Cancer Biology
    2. Cell Biology

    Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion

    Akikazu Harada, Shinji Matsumoto ... Akira Kikuchi
    Specific localization of KRAS downstream target ARL4C with its novel interacting proteins was the active site of invasion of pancreatic cancer cell and induced metastasis.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a

    Yuta Nakazawa, Nanako Nishiyama ... Akira Shibuya
    Tumor-infiltrating regulatory T cells are regulated by the immunoreceptor CD300a, which suppresses signals from tumor-derived extracellular vesicles.
    1. Cancer Biology

    The role of TAp63γ and P53 point mutations in regulating DNA repair, mutational susceptibility and invasion of bladder cancer cells

    Hsiang-Tsui Wang, Hyun-Wook Lee ... Moon-shong Tang
    Biochemical analysis shows that muscle-invasive-bladder-cancer cells are deficient in DNA repair and hypermutable, non-muscle-invasive-bladder-cancer cells are proficient in DNA repair, DNA repair capacity is regulated by tumor suppressor TAp63g, and cell invasions are regulated by TAp63g and p53.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

    E Josue Ruiz, Adan Pinto-Fernandez ... Axel Behrens
    Deletion and small-molecule inhibition of ubiquitin-specific protease 28 destabilizes the oncogenes c-MYC, c-JUN, and Δp63, and elicits regression of squamous cell lung carcinoma, a major cancer type with currently limited treatment options.
    1. Cancer Biology
    2. Cell Biology

    RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

    Tomasz Radaszkiewicz, Michaela Nosková ... Vítězslav Bryja
    RNF43 interacts with receptor complexes of the Wnt/PCP signaling and its enzymatic activity results in the reduced cells sensitivity to WNT5A what translates in melanoma into decreased invasive properties and increased response to targeted therapies of this skin cancer.
    1. Cancer Biology
    2. Neuroscience

    Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice

    Susu Pan, Kaili Yin ... Guo Zhang
    Assessments using chemogenetic and pharmacological approaches reveal that modulation of the activities of oxytocin neurons in the hypothalamus of the central nervous system could inhibit colorectal cancer progression in mice.
    1. Cancer Biology
    2. Computational and Systems Biology

    Integrated evaluation of telomerase activation and telomere maintenance across cancer cell lines

    Kevin Hu, Mahmoud Ghandi, Franklin W Huang
    Comprehensive analysis of telomere maintenance from transcriptomic, epigenetic, and loss-of-function profiles of cancer cell lines elucidates features of telomere regulation in cancer.
    1. Cancer Biology
    2. Cell Biology

    Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation

    Brian Spurlock, Danitra Parker ... Kasturi Mitra
    A mitochondria-based 'priming' of stemness happens by fine-tuned repression of the level or activity of the master regulator of mitochondrial fission, Drp1, which supports carcinogen-induced transformation in a keratinocyte model.