Browse our latest Cancer Biology articles

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    1. Cancer Biology
    2. Epidemiology and Global Health

    Effect of cancer on outcome of COVID-19 patients: a systematic review and meta-analysis of studies of unvaccinated patients

    Giulia Di Felice, Giovanni Visci ... Paolo Boffetta
    A twofold increased risk of adverse outcomes (mortality, ICU admission, and severity of COVID-19) has been demonstrated in unvaccinated COVID-19 patients with cancer compared to COVID-19 patients without cancer.
    1. Cancer Biology
    2. Cell Biology

    Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy

    Leying Chen, Qing You ... Shiyi Zhang
    Modulation of dermal adipocytes contributes to skin homeostasis and provides a promising new therapeutic strategy in the treatment of EGFRI-related skin disorders.
    1. Cancer Biology

    Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth

    Elena Vasileva, Mikako Warren ... James F Amatruda
    A zebrafish genetic model of Ewing sarcoma, a pediatric bone cancer, showed how molecules in the normal tissue can support tumor cells, and identified a therapeutic compound that slows tumor growth.
    1. Cancer Biology
    2. Cell Biology

    The out-of-field dose in radiation therapy induces delayed tumorigenesis by senescence evasion

    Erwan Goy, Maxime Tomezak ... Corinne Abbadie
    Irradiation of normal human fibroblasts and mice in conditions mimicking standard external X-ray radiotherapy protocols highlights that noncancerous cells surrounding the planning target volume accumulate DNA single-strand breaks but almost no double-strand breaks, putting them in a pre-cancerous senescent state.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations

    H Nayanga Thirimanne, Feinan Wu ... Bruce E Clurman
    Genome-wide analyses reveal how tumor-associated mutations of the Fbw7 ubiquitin ligase impact oncogenic transcription factors and gene expression.
    1. Cancer Biology
    2. Computational and Systems Biology

    Signature-scoring methods developed for bulk samples are not adequate for cancer single-cell RNA sequencing data

    Nighat Noureen, Zhenqing Ye ... Siyuan Zheng
    Dropouts in single cell RNA sequencing data are associated with cell states and can affect gene signature scoring if methods do not account for them.
    1. Cancer Biology
    2. Cell Biology

    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

    Deborah Fanfone, Zhichong Wu ... Gabriel Ichim
    A biomechanical approach inducing confined cell migration reveals that mechanical stress has a profound effect on cancer cell survival.
    1. Cancer Biology

    A survey of optimal strategy for signature-based drug repositioning and an application to liver cancer

    Chen Yang, Hailin Zhang ... Hui Wang
    Computational and experimental analyses show that homoharringtonine may be repurposed as an agent for the treatment and prevention of liver cancer.
    1. Cancer Biology
    2. Cell Biology

    Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells

    Alejandro La Greca, Nicolás Bellora ... Patricia Saragüeta
    Binding of progesterone receptor and transcription factor PAX2 to pre-assembled permissive chromatin compartments regulates endometrial cancer gene expression under estrogenic conditions.
    1. Cancer Biology

    Serum RNAs can predict lung cancer up to 10 years prior to diagnosis

    Sinan U Umu, Hilde Langseth ... Trine B Rounge
    Prediagnostic RNA levels show early lung cancer progression.