Browse our latest Cancer Biology articles

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    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    UBE2G1 governs the destruction of cereblon neomorphic substrates

    Gang Lu, Stephanie Weng ... Mark Rolfe
    Cereblon-based small-molecule degraders rely on the sequential action of ubiquitin-conjugating enzymes UBE2G1 and UBE2D3 to assemble K48-linked polyubiquitin chains on cereblon neomorphic substrates, resulting in their proteasomal degradation.
    1. Cancer Biology

    Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

    Kathryn Eaton, Ali Pirani ... Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
    1. Cancer Biology
    2. Medicine

    Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death

    Haley Hieronymus, Rajmohan Murali ... Charles L Sawyers
    The percentage of a tumor’s genome with alterations in copy number is correlated with increased mortality across a range of tumor types and can be measured using a clinically approved sequencing assay.
    1. Cancer Biology
    2. Cell Biology

    Aurora kinase A localises to mitochondria to control organelle dynamics and energy production

    Giulia Bertolin, Anne-Laure Bulteau ... Marc Tramier
    AurkA is imported into mitochondria at interphase, and it induces organelle elongation and enhances ATP production when over-expressed.
    1. Cancer Biology
    2. Immunology and Inflammation

    Topography of cancer-associated immune cells in human solid tumors

    Jakob Nikolas Kather, Meggy Suarez-Carmona ... Niels Halama
    Spatial patterns of lymphoid and myeloid cells in human solid tumors differ between cancer types, yielding a new classification of anti-tumor host response.
    1. Cancer Biology

    tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

    Myron S Ignatius, Madeline N Hayes ... David M Langenau
    Syngeneic tp53-null zebrafish develop a wide range of tumors that engraft into recipient animals with loss of Tp53 leading to increased metastasis in embryonal rhabdomyosarcoma (ERMS), likely accounting for increased aggression in TP53-inactivated human ERMS.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

    Ethan V Abel, Masashi Goto ... Diane M Simeone
    HNF1A, a risk factor gene for pancreatic ductal adenocarcinoma, is critical to maintaining pancreatic cancer stem cell properties through regulating POU5F1 (OCT4) expression, providing a novel role for HNF1A in maintenance of the disease.
    1. Cancer Biology
    2. Cell Biology

    An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

    Ji Li, Peter S Choi ... William C Hahn
    Splicing by QKI and RBFOX1 regulates the function of the actin-binding protein FLNB by creating an isoform frequently observed in human cancers that dictates tumor cell plasticity.
    1. Cancer Biology
    2. Immunology and Inflammation

    Contagious Cancers: A ‘devil’ of a problem

    Victoria L Hansen, Robert D Miller
    The discovery of a second facial tumor disease in the Tasmanian devil has provided insights into the emergence of contagious cancers.
    Version of Record
    Insight
    1. Cancer Biology
    2. Immunology and Inflammation

    The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

    Alison Caldwell, Rachel Coleby ... Hannah VT Siddle
    A recently discovered contagious cancer in the Tasmanian devil has the potential to become widespread in the population due to the loss of histocompatibility antigens that are allogeneic to its hosts.