Browse our latest Cancer Biology articles

Syngeneic tp53-null zebrafish develop a wide range of tumors that engraft into recipient animals with loss of Tp53 leading to increased metastasis in embryonal rhabdomyosarcoma (ERMS), likely accounting for increased aggression in TP53-inactivated human ERMS.

HNF1A, a risk factor gene for pancreatic ductal adenocarcinoma, is critical to maintaining pancreatic cancer stem cell properties through regulating POU5F1 (OCT4) expression, providing a novel role for HNF1A in maintenance of the disease.

Splicing by QKI and RBFOX1 regulates the function of the actin-binding protein FLNB by creating an isoform frequently observed in human cancers that dictates tumor cell plasticity.

The discovery of a second facial tumor disease in the Tasmanian devil has provided insights into the emergence of contagious cancers.

A recently discovered contagious cancer in the Tasmanian devil has the potential to become widespread in the population due to the loss of histocompatibility antigens that are allogeneic to its hosts.

t-CyCIF can be used to collect spatially-encoded, multiparametric data from fixed and embedded research or clinical specimens making it possible to probe the organization of tumors and tissues at a single-cell level.

Slow conformational changes after drug binding rationalize selectivity, affinity and long on-target residence time for kinase inhibitors.

Chromatin remodeling processes can drive acinar cell fate decisions.

Arid1a loss in the pancreas enables an irreversible reprogramming of cell fate that is dependent on both cellular and genetic context.

A biosensor resource has been developed to monitor the intracellular interactions of RAS family proteins with effector molecules and the effects of inhibitors as an aid to drug development.