Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology

    SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model and its catalytic activity is regulated by histone acetylation

    Ricardo J Mack, Natasha M Flores ... Or Gozani
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology

    Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

    Youyou Zhang, Mu Xu ... Lin Zhang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease
    2. Cancer Biology

    The lnc-FANCI-2 intrinsically restricts RAS signaling in HPV16-infected cervical cancer

    Haibin Liu, Lulu Yu ... Zhi-Ming Zheng
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cancer Biology

    Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single cell RNA sequencing

    Einav Someach, Debdatta Halder ... Itay Tirosh
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

    Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology

    Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain

    Cassandra C Taber, Wenguang He ... Michael Ohh
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

    Ravi Kumar, Simon Couly ... Ashish Lal
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Cancer Biology
    2. Medicine

    Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis

    Yiran Zhang, Hanyang Guan ... Jinghua Pan
    Patients with microsatellite stable/low microsatellite instability mismatch repair-proficient metastatic colorectal cancer may be sensitive to tislelizumab treatment after receiving Gamma Knife stereotactic radiotherapy.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Cancer: Reading the DNA of telomeres

    Shamayita Roy, Claus M Azzalin
    Experiments with tools designed to detect DNA damage reveal unique and conserved features of telomeres in cancer cells.
    Version of Record
    Insight
    1. Cancer Biology

    A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning

    Kailai Li, Junyi Liang ... Hui Meng
    A machine learning-derived multi-gene score effectively predicts radiation sensitivity in nasopharyngeal carcinoma by integrating immune characteristics and radiosensitivity-related pathways.
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Highlights

    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Reading the DNA of telomeres

    Shamayita Roy, Claus M Azzalin
    1. Cancer Biology

    Reproducibility in Cancer Biology

    Edited by Roger J Davis et al.
    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Eduardo Franco
    McGill University, Canada
  3. Caigang Liu
    Shengjing Hospital of China Medical University, China
  4. See more editors