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MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression
Timothy J Aikin et al.
The temporal patterns of MAPK activity differentially regulate cell autonomous and non-cell autonomous effects of oncogene expression.
Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling
Yingqi Liu et al.
PRMT7-mediated SHANK2 methylation regulates breast cancer metastasis by activating endosomal FAK signals, and may provide potential clues for tumour metastasis treatment strategies.
, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation
Li Pan et al.
PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
Chiho Kim et al.
Identification of PARP1 trapping as the major contributor of PARP1 inhibitor-induced innate immune response.
Stem Cells and Regenerative Medicine
A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors
Laura Crowley et al.
Physics of Living Systems
Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy
Xin Cui et al.
A biomimetic and patient-specific Glioblastoma-on-a-Chip microphysiological system provides an avenue for personalized screening of PD-1 immunotherapy and novel combinational therapies that maximize therapeutic outcomes in Glioblastoma patients.
SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells
Erik Oliemuller et al.
Chromosomes and Gene Expression
Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones
Jay F Sarthy et al.
Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer
Patricia L Theard et al.
Combined EGFR and SOS1 inhibition synergize to inhibit NSCLC spheroid growth.
Immunology and Inflammation
A perspective on HPK1 as a novel immuno-oncology drug target
Sansana Sawasdikosol, Steven Burakoff
HPK1 is an important immuno-oncology drug target that may induce superior anti-tumor immunity through the multiple roles HPK1 may play at multiple steps of the cancer immunity cycle.
Toxicity: Fishing for protective compounds
Biochemistry and Chemical Biology
Anti-Cancer Drugs: The mitochondrial paradox
Sophie L Penman et al.
Reproducibility in Cancer Biology
Edited by Roger J Davis et al.
University of California, Los Angeles, United States
Fox Chase Cancer Center, United States
The Wistar Institute, United States
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