Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Genetics and Genomics

   BRAF^V600E induces reversible mitotic arrest in human melanocytes via microrna-mediated suppression of AURKB

   Andrew S McNeal et al.

   Oncogenic BRAF causes genome duplication and reversible growth arrest in human melanocytes that is conditional on microRNA expression and differentiation state.
2. 1. Cancer Biology
   2. Cell Biology

   Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion

   Akikazu Harada et al.

   Specific localization of KRAS downstream target ARL4C with its novel interacting proteins was the active site of invasion of pancreatic cancer cell and induced metastasis.
3. 1. Cancer Biology
   2. Cell Biology

   Heat Shock Factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells

   Natalia Vydra et al.
4. 1. Cancer Biology

   ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer

   Wentong Fang et al.
5. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

   Xiao-Tong Lin et al.
6. 1. Cancer Biology
   2. Immunology and Inflammation

   Tumor-derived extracellular vesicles regulate tumor-infiltrating regulatory T cells via the inhibitory immunoreceptor CD300a

   Yuta Nakazawa et al.

   Tumor-infiltrating regulatory T cells are regulated by the immunoreceptor CD300a, which suppresses signals from tumor-derived extracellular vesicles.
7. 1. Cancer Biology

   The role of TAp63γ and P53 point mutations in regulating DNA repair, mutational susceptibility and invasion of bladder cancer cells

   Hsiang-Tsui Wang et al.

   Biochemical analysis shows that muscle-invasive-bladder-cancer cells are deficient in DNA repair and hypermutable, non-muscle-invasive-bladder-cancer cells are proficient in DNA repair, DNA repair capacity is regulated by tumor suppressor TAp63g, and cell invasions are regulated by TAp63g and p53.
8. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

   E Josue Ruiz et al.

   Deletion and small-molecule inhibition of ubiquitin-specific protease 28 destabilizes the oncogenes c-MYC, c-JUN, and Δp63, and elicits regression of squamous cell lung carcinoma, a major cancer type with currently limited treatment options.
9. 1. Cancer Biology
   2. Cell Biology

   RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

   Tomasz Radaszkiewicz et al.

   RNF43 interacts with receptor complexes of the Wnt/PCP signaling and its enzymatic activity results in the reduced cells sensitivity to WNT5A what translates in melanoma into decreased invasive properties and increased response to targeted therapies of this skin cancer.
10. 1. Cancer Biology
    2. Neuroscience

    Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice

    Susu Pan et al.

    Assessments using chemogenetic and pharmacological approaches reveal that modulation of the activities of oxytocin neurons in the hypothalamus of the central nervous system could inhibit colorectal cancer progression in mice.