Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology
    2. Computational and Systems Biology

    Comprehensive characterization of tumor microenvironment in colorectal cancer via molecular analysis

    Xiangkun Wu, Hong Yan ... Li Liang
    Integrated molecular analysis demonstrated that colorectal cancer can be classified into four molecular subtypes (proliferative, immunomodulatory, immunosuppressed, and immune-excluded subtypes), providing valuable insight into the intricate relationship between tumor microenvironment heterogeneity and various clinical phenotypes.
    1. Cancer Biology

    Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes

    Aojia Zhuang, Aobo Zhuang ... Chen Ding
    Based on the proteomics results, T1 CRC LNM prediction models were built using machine learning, the functional differences and biomarkers between LNM-negative and LNM-positive patients were revealed.
    1. Cancer Biology

    The CD73 immune checkpoint promotes tumor cell metabolic fitness

    David Allard, Isabelle Cousineau ... John Stagg
    1. Cancer Biology
    2. Genetics and Genomics

    MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

    Changyu Zhu, Yadira M Soto-Feliciano ... Scott W Lowe
    1. Cancer Biology
    2. Computational and Systems Biology

    GENIUS: GEnome traNsformatIon and spatial representation of mUltiomicS data

    Mateo Sokač, Lars Dyrskjøt ... Nicolai J Birkbak
    1. Cancer Biology
    2. Computational and Systems Biology

    Predictive nonlinear modeling of malignant myelopoiesis and tyrosine kinase inhibitor therapy

    Jonathan Rodriguez, Abdon Iniguez ... Richard A Van Etten
    A physiological mathematical model of chronic myeloid leukemia, validated by experiments in transgenic mice and clinical data, identifies mechanisms underlying the response to tyrosine kinase inhibitor therapy, predicts biomarkers of primary resistance, and suggests new strategies to improve treatment outcomes.
    1. Cancer Biology

    DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

    Nicholas J. Mullen, Surendra K. Shukla ... Pankaj K. Singh

Senior editors

  1. Utpal Banerjee
    University of California, Los Angeles, United States
  2. Wafik S El-Deiry
    Brown University, United States
  3. Eduardo Franco
    McGill University, Canada
  4. See more editors