Cancer Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

   Zoe A Stephenson et al.

   A novel toxicophore, a 1H-1,2,3-triazole, has been identified in a wide-number of therapeutically-relevant compounds, including two anti-cancer chemotherapeutics, which inhibits mitochondria function and is mechanistically linked to adverse cardiac-cell events.
2. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Anti-Cancer Drugs: The mitochondrial paradox

   Sophie L Penman et al.

   A structural motif that is found in two cancer drugs may be responsible for their ability to tackle cancers and for the side-effects caused by the drugs.
3. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   AR phosphorylation and CHK2 kinase activity regulates IR stabilized AR-CHK2 interaction and prostate cancer survival

   Huy Q Ta et al.
4. 1. Cancer Biology

   Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

   Caroline Contat et al.

   In lung adenocarcinoma, deleting one glucose transporter, whether it is Glut1 or Glut3 is insufficient, whereas their dual deletion reduces tumor growth.
5. 1. Cancer Biology

   The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer

   Zane A Gibbs et al.

   Anomalous expression of the testis protein ZNF165 in cancer cells promotes assembly of a neomorphic transcriptional complex that modulates transcription of TGFβ target genes to support tumor cell survival.
6. 1. Cancer Biology
   2. Human Biology and Medicine

   MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans

   Calvin VanOpstall et al.
7. 1. Cancer Biology

   MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation

   Seiji Arai et al.

   MARCH5 mediates a pathway driving MCL1 degradation in response to cellular stress, which sensitizes to BH3 mimetic drugs targeting BCLXL and provides a broadly effective therapeutic strategy for solid tumors.
8. 1. Cancer Biology
   2. Computational and Systems Biology

   Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions

   Christopher J Lord et al.

   Computational approach to identify reproducible genetic interactions in cancer reveals that they are enriched among protein–protein interaction pairs.
9. 1. Cancer Biology
   2. Immunology and Inflammation

   

   Discovery and Translation of Cancer Immunology: A Special Issue

   Edited by Jeffrey Settleman et al.

   eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of the immune response to cancer cells.
10. 1. Cancer Biology
    2. Genetics and Genomics

    FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restriction

    Avantika Gupta, Hugo Stocker

    Transcriptomic and genetic analyses of FoxO target genes reveal a key function of ER-associated protein degradation in growth regulation of Tsc1-deficient tissues.