Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Stem Cells and Regenerative Medicine

   RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

   Máté Nászai et al.

   Combined genetic experiments and cellular trafficking assays in Drosophila and mammalian models uncover a new role of RAS-like GTPases in EGFR signalling activation during tissue regeneration and tumourigenesis through regulation of EGFR internalisation.
2. 1. Cancer Biology

   Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation

   Xin Zhou et al.
3. 1. Cancer Biology
   2. Cell Biology

   Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

   Kerrie-Ann McMahon et al.
4. 1. Biochemistry and Chemical Biology
   2. Cancer Biology

   Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

   Margaret A M Nelson et al.
5. 1. Cancer Biology

   Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

   Alba Nicolas-Boluda et al.

   Tumor stiffness blocks T cell migration in tumors.
6. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence

   Shou Liu et al.

   ARID1A deficiency in SWI/SNF complex promotes pancreatic tumor development by upregulating ALDH protein levels to effectively reduce cellular reactive oxygen species levels, leading to the significant attenuation of oncogenic KRAS-induced senescence.
7. 1. Cancer Biology

   Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

   M Ines Pascoal Ramos et al.
8. 1. Cancer Biology

   Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

   Yusuke Inoue et al.
9. 1. Cancer Biology
   2. Cell Biology

   KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition

   Chaitra Rao et al.

   A key Ras-driven signaling pathway stimulates the preferential translation of an effector, EPSTI1, that is both necessary and sufficient for the epithelial-to-mesenchymal transition-like phenotype in colorectal cancer cells.
10. 1. Cancer Biology

    A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis

    Jia Li et al.

    A genome-wide in vivo CRISPR screen identifies an IL-20/IL20RA-mediated crosstalk between peritoneum mesothelial cells and ovarian cancer cells that promotes the formation of M1-like macrophages to prevent ovarian cancer metastasis.