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The solubility product, a thermodynamic concept classically applied to poorly soluble ionic solutes, can rationalize the concentration dependence for liquid-liquid phase separation of multicomponent multivalent molecules.

Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.

Extended biochemical and functional analyses in primary neurons show that early neuronal morphogenesis critically relies on cooperation of the actin nucleator Cobl and its ancestor Cobl-like and uncover their cooperative mechanisms at dendritic branch initiation sites.

Cavin3 associates with BRCA1 upon disassembly of caveolae in response to mechanical and non-mechanical stressors to influence DNA repair and apoptosis.

Akt phosphorylates insulin receptor substrate to engage negative feedback and limit signal propagation.

Unique integrate stress response sensors differentially trigger pro-survival versus pro-apoptotic responses in cells confronted with Hsp70 inhibitor-associated proteotoxic challenges.

Embryonic and mechanical manipulations of Xenopus multiciliated epithelium reveals that cell non-autonomous tensile forces generated by embryonic elongation calibrate cilia number in multiciliated cells via a mechanosensitive ion channel, Piezo1.

Epithelial cells coordinate integrin signaling with protrusion via a two-protein module, with one protein defining localization and downstream signaling, the other serving as a phosphorylation switch and providing negative feedback.

Single-cell mRNA sequencing on hemocytes of penaeid shrimp revealed six types of hemocytes, type markers, differentiation pathways, and different immune roles among these subpopulations based on their transcriptional profiles.

Inverse gradients of cell ingression and division in the epiblast allow the bipotent progenitors in the anterior streak to become the main progenitors for posterior axis formation from the tail bud.