Javier Emperador-Melero, Giovanni de Nola, Pascal S Kaeser
Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are precisely localized to synaptic appositions, but do not control the assembly and function of the presynaptic nerve terminal.
Spatial restriction of GPCR signaling at nascent synapses by adhesion complexes drives excitatory synapse formation and specificity in the hippocampus.
Taylor B Updegrove, Jailynn Harke ... Kumaran S Ramamurthi
Reengineering the nucleotide-binding pocket of an extant ATPase to restore ancestral GTPase activity revealed an ATP-dependent intermediate required for function and suggested why the protein evolved to use ATP.
Leonie Zeitler, Alessandra Fiore ... Peter J Murray
IL4i1 is an amino acid oxidase expressed in the mammalian immune system and snake venoms, which control diametrically opposite cell protection versus cell death pathways, respectively.
A neuromodulatory circuit bidirectionally regulates the glial capacity to buffer ions and water in response to changes in neuronal excitation in order to balance glial versus neuronal protection.